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2 postsInhibition of mitochondrial NADH:ubiquinone oxidoreductase by spinning oscillating magnetic fields causes toxicity in cancer cells
This in vitro study examines a spinning oscillating magnetic field (sOMF) generated by an Oncomagnetic device and reports selective toxicity in glioma cancer cells. The abstract attributes effects to ROS-dependent inhibition of mitochondrial complex I, with downstream oxidative stress, DNA damage, cell-cycle arrest, and apoptosis. It also reports no similar toxic effects in normal human astrocytes/astroglial cells under the studied conditions.
Mitigation of 3.5 GHz Electromagnetic Field-Induced BV2 Microglial Cytotoxicity by Polydeoxyribonucleotide
This in vitro study exposed BV2 mouse microglial cells to 3.5 GHz EMF for 2 hours and reports reduced cell growth and increased apoptosis alongside oxidative stress and signaling changes. The authors report that ROS generation and activation of JNK-1/2 and p38 MAPK were key events in the observed cytotoxicity. Polydeoxyribonucleotide (PDRN) reportedly reduced several EMF-associated cytotoxicity markers, suggesting a potential mitigating effect under the tested conditions.