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8 postsThe International Collaborative Animal Study of Mobile Phone Radiofrequency Radiation Carcinogenicity and Genotoxicity: The Japanese Study
This PubMed-listed animal study reports results from the Japanese arm of an international Japan–Korea collaboration evaluating whether long-term mobile-phone-like RF-EMF exposure causes cancer or genetic damage in rats. Male Sprague Dawley rats were exposed to 900 MHz CDMA-modulated RF-EMF at a whole-body SAR of 4 W/kg for nearly 18.5 hours/day over two years, alongside OECD/GLP genotoxicity and carcinogenicity testing. The authors report no statistically significant increases in neoplastic or non-neoplastic lesions in major organs and no evidence of DNA or chromosomal damage, concluding the findings do not support reproducible carcinogenic or genotoxic effects under these conditions.
The International Collaborative Animal Study of Mobile Phone Radiofrequency Radiation Carcinogenicity and Genotoxicity: The Japanese Study
This international collaborative animal study (Japanese arm) evaluated carcinogenicity and genotoxicity in male Sprague Dawley rats exposed long-term to 900 MHz CDMA-modulated RF-EMFs at 4 W/kg whole-body SAR. The abstract reports no statistically significant increases in neoplastic or non-neoplastic lesions in major organs and no evidence of genotoxicity on comet or micronucleus testing. The authors conclude the findings provide strong evidence of no reproducible carcinogenic or genotoxic effects under the studied conditions.
The animal carcinogenicity evidence is no longer reasonably dismissible
RF Safe argues that animal evidence for RF-related carcinogenicity is now strong and should not be dismissed, citing the NTP (2018) and Ramazzini (2018) lifetime rodent studies as showing statistically significant increases in the same rare tumor types (heart schwannomas and brain gliomas). The post further claims that effects occurred at relatively low whole-body SAR levels and references additional mechanistic hypotheses (e.g., VGCC-related models and radical-pair/spin effects) and a reported human ultrasound observation of acute non-thermal changes. These points are presented as supporting a shift away from a “thermal-only” interpretation, but the item is advocacy/commentary and does not provide full methodological details in the excerpt.
This is one of the most coherent, mechanistically grounded syntheses I’ve seen linking non-thermal RF/ELF effects across cancer, reproductive harm, and immune dysregulation
An RF Safe commentary argues that a proposed “S4–mitochondria axis” provides a coherent mechanism for non-thermal RF/ELF biological effects, linking voltage-gated ion channel (VGIC) disruption to altered calcium signaling, mitochondrial ROS, and downstream cancer, reproductive, and immune impacts. The post cites several recent reviews and systematic reviews (including a WHO-commissioned animal carcinogenicity review and an SR4A corrigendum) as strengthening evidence for specific tumor and reproductive outcomes in animals. It concludes that regulatory positions emphasizing thermal limits and lack of mechanism are no longer defensible, presenting this as convergent evidence rather than scattered findings.
The S4-Mitochondria Axis: A Plausible Unifying Mechanism for Non-Thermal Radiofrequency Electromagnetic Field Effects on Cancer, Male Reproduction, Carcinogenicity, and Immune Dysregulation
RF Safe argues that findings it describes as “high-certainty” from WHO-commissioned systematic reviews show RF-EMF causes malignant heart Schwannomas and brain gliomas in rodents and reduces male fertility. The post proposes a unifying non-thermal mechanism—the “S4-mitochondria axis”—suggesting RF-EMF interacts with the voltage-sensing S4 helix of voltage-gated ion channels (VGICs) and is amplified by mitochondrial density. It concludes that the combination of animal evidence and a proposed mechanism supports precautionary revisions to exposure guidelines and more mechanistic research.
Simultaneous 4G and 5G EMF Exposure and Field Uniformity in a Reverberation Chamber for Animal Studies
This engineering study describes the design and validation of a reverberation chamber intended for large-scale animal carcinogenicity research with RF EMF relevant to 4G/5G. E-field uniformity was tested under four loading scenarios, including setups with 80 Sprague-Dawley rats. The chamber achieved better than 1.36 dB E-field uniformity across scenarios, and the authors report a method to predict composite E-field intensity for simultaneous multi-frequency exposures.
Carcinogenicity of Radio-Frequency Radiation: Similarities and Differences Between Outcomes of Two Studies
This review compares two epidemiologic studies of radio-frequency radiation (RFR) exposure among military personnel with overlapping patient groups. One study reported a statistically significant increase in cancer among exposed individuals, while the other did not, which the review attributes to a smaller sample size. The review highlights similar cancer patterns across both studies, including a high proportion of hematolymphoid cancers and earlier onset among exposed individuals, and interprets these similarities as evidence of carcinogenic effects.
Carcinogenicity of extremely low-frequency magnetic fields: A systematic review of animal studies
This PRISMA-based systematic review evaluated 54 animal studies on the carcinogenicity of extremely low-frequency (ELF) magnetic fields. The authors report very little evidence that ELF magnetic fields alone are carcinogenic. Findings on co-carcinogenicity (ELF MFs combined with other agents) are inconclusive, and the review notes a clear indication of publication bias.