Acute exposure to 27.12 MHz radiofrequency electromagnetic field disrupts blood-brain barrier integrity via eNOS activation and occludin down-regulation.
Research
RF Safe Research Library
Jan 1, 2025
This animal study examined 27.12 MHz RF-EMF exposure for 30, 180, or 360 minutes in female Wistar rats and assessed markers related to blood-brain barrier integrity. The authors report increased eNOS expression after 30 minutes without oxidative stress or inflammation, alongside decreased occludin expression. Longer…
Treatment of glioblastoma with tumor-specific amplitude-modulated radiofrequency electromagnetic fields.
Research
RF Safe Research Library
Jan 1, 2025
This study reports that glioblastoma-specific amplitude-modulated 27.12 MHz RF electromagnetic fields (delivered intrabuccally) inhibited proliferation in several glioblastoma cell lines exposed 3 hours/day at patient-matched levels. The authors propose a mechanism involving CACNA1H and modulation of the “Mitotic…
Low-energy amplitude-modulated radiofrequency electromagnetic fields as a systemic treatment for cancer: Review and proposed mechanisms of action
Research
RF Safe Research Library
Sep 8, 2022
This review discusses low-energy amplitude-modulated RF EMF (27.12 MHz carrier with low Hz–kHz envelope modulation) delivered systemically via intrabuccal antenna devices as a potential treatment for advanced hepatocellular carcinoma. It reports preclinical inhibition of cancer growth in vitro and in mouse xenograft…
Safety and Efficacy of amplitude-modulated radiofrequency electromagnetic fields in advanced hepatocellular carcinoma
Research
RF Safe Research Library
Jan 1, 2021
This pooled case series evaluated amplitude-modulated 27.12 MHz RF EMF delivered via the TheraBionic P1 device (3 hours daily) in patients with advanced hepatocellular carcinoma, comparing outcomes to historical controls. The authors report longer median overall survival for Child-Pugh A patients versus comparable…
Ca2+ and CACNA1H mediate targeted suppression of breast cancer brain metastasis by AM RF EMF
Research
RF Safe Research Library
Jan 1, 2019
This study describes a therapeutic use of athermal, amplitude-modulated RF EMF (27.12 MHz) at breast cancer-specific frequencies to target breast cancer brain metastases. The abstract reports tumor growth suppression in animal models and durable regression in one patient with triple negative breast cancer brain…