Acute exposure to 27.12 MHz radiofrequency electromagnetic field disrupts blood-brain barrier integrity via eNOS activation and occludin down-regulation.
This animal study examined 27.12 MHz RF-EMF exposure for 30, 180, or 360 minutes in female Wistar rats and assessed markers related to blood-brain barrier integrity. The authors report increased eNOS expression after 30 minutes without oxidative stress or inflammation, alongside decreased occludin expression. Longer exposures were associated with hypoxia marker upregulation, reduced tight junction proteins, and histopathological signs of hyperemia and edema, especially in cerebellum.
Key points
- Female Wistar rats were exposed to 27.12 MHz RF-EMF for 30, 180, or 360 minutes (n=6 per group).
- Thirty-minute exposure increased eNOS gene expression without reported oxidative stress or inflammatory changes.
- Occludin expression was reported to decrease in all exposure groups.
- Longer exposures (180/360 minutes) were associated with increased HIF-1α and decreased claudin-1 and occludin.
- Histopathological findings of hyperemia and edema were reported, particularly in cerebellar tissue, after longer exposures.
- The authors interpret short exposure as transient BBB modulation without apparent tissue damage and propose potential drug-delivery applications.
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AI-generated summaries may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.
AI-generated summaries may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.
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