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Filters: tag: Hippocampus Clear

Dose-dependent impact of extremely low-frequency electromagnetic field (ELF-EMF) on the neuroplasticity in the hippocampus of adult rats.

Research RF Safe Research Library Jan 1, 2026

This animal study examined whether 50 Hz ELF-EMF exposure at two intensities (1 mT vs 7 mT) alters hippocampal gene transcripts related to neuroplasticity and cell survival in adult rats across repeated exposure cycles. The authors report intensity- and exposure-number-dependent modulation of mRNA expression, with 1…

Possible effects of RF EMR on contextual fear conditioning, hippocampal perivascular space, apoptosis and adrenal gland microarchitecture in rats

Research RF Safe Research Library Jan 1, 2025

This animal study exposed male Wistar rats to 900 MHz RF-EMR from a mobile phone for 1 hour daily over four weeks and assessed behavior and tissue changes. The authors report altered contextual fear conditioning-related behavior in exposed rats. Histological assessments indicated apoptosis and enlarged perivascular…

Effects of electromagnetic field emitted by a 90 kHz WPT system on the cognitive functions and neuronal excitation of mice.

Research RF Safe Research Library Jan 1, 2025

This animal study examined whether EMF from a 90 kHz magnetic-coupling resonant wireless power transfer (WPT) system affects mouse cognition and hippocampal neuronal excitability. Mice were exposed for 2, 4, or 8 weeks and assessed with a Novel Object Recognition test and dentate gyrus patch-clamp recordings. The…

Effect of ELF-EMF on cognitive functions, analgesia, and oxidative stress in rats with PTZ-induced epilepsy.

Research RF Safe Research Library Jan 1, 2025

This animal study tested repeated 50 Hz, 5 mT ELF-EMF exposure in rats with and without PTZ-induced epilepsy. The authors report changes in learning/short-term memory in the EMF+PTZ group versus PTZ alone and increased analgesia latency in EMF-exposed groups. PTZ increased oxidative stress (TOS) in brain regions, and…

Electromagnetic fields modulate neuronal membrane ionic currents through altered cellular calcium homeostasis.

Research RF Safe Research Library Jan 1, 2025

This experimental study used loose patch clamp recordings in coronal hippocampal slices to test effects of extremely low-frequency EMF exposure. A 50 Hz, 1 mT field applied for 60 minutes decreased inward and transient outward currents in CA1 pyramidal neuron membranes. Pharmacological manipulation of intracellular…

The extremely low-frequency electromagnetic field (50 Hz) can establish a new "set-point" for the activity of the locus coeruleus-noradrenergic (LC-NA) system in rat.

Research RF Safe Research Library Jan 1, 2024

This animal study exposed rats to 50 Hz ELF-EMF at 1 mT or 7 mT for 1 hour/day over 7 days, repeated across three cycles, and assessed catecholamines, MHPG, β2-adrenergic receptor expression, and behavior. The authors report that ELF-EMF influences stress-response mechanisms involving the locus…

Effects of Head-Only Exposure to 900 MHz GSM Electromagnetic Fields in Rats: Changes in Neuronal Activity as Revealed by c-Fos Imaging without Concomitant Cognitive Impairments.

Research RF Safe Research Library Jan 1, 2024

This rat study used a head-only 900 MHz GSM exposure system to assess brain activity changes via c-Fos imaging and to test spatial memory performance. Acute exposure (2 h) was associated with dose-dependent, region-specific increases in c-Fos expression, while repeated pre-training exposures were associated with…

Effect of prenatal exposure to stress and extremely low-frequency electromagnetic field on hippocampal and serum BDNF levels in male adult rat offspring.

Research RF Safe Research Library Jan 1, 2024

This rat study examined prenatal stress, prenatal ELF-EMF exposure, and their combination on adult male offspring outcomes at postnatal day 90. Prenatal stress increased serum corticosterone but did not change spatial memory, while combined stress+ELF-EMF disrupted memory acquisition. ELF-EMF exposure was associated…

Lipoic acid inhibits cognitive impairment induced by multiple cell phones in young male rats: role of Sirt1 and Atg7 pathway.

Research RF Safe Research Library Jan 1, 2023

This animal study examined whether lipoic acid modifies cognitive and hippocampal effects in young male rats exposed to EMF emitted from multiple cell phones. The authors report improved learning performance but impaired long-term memory consolidation after EMF exposure, alongside changes in hippocampal…

Extremely Low-Frequency Electromagnetic Stimulation (ELF-EMS) Improves Neurological Outcome and Reduces Microglial Reactivity in a Rodent Model of Global Transient Stroke.

Research RF Safe Research Library Jan 1, 2023

This animal and laboratory study evaluated extremely low-frequency electromagnetic stimulation (ELF-EMS) in a rodent ischemia-reperfusion stroke model and related in vitro/slice experiments. The authors report improved neurological and behavioral outcomes, increased neuronal survival, and reduced glial/microglial…

Impact of ketamine administration on chronic unpredictable stress-induced rat model of depression during extremely low-frequency electromagnetic field exposure: Behavioral, histological and molecular study.

Research RF Safe Research Library Jan 1, 2023

This animal study evaluated ketamine administration combined with extremely low-frequency electromagnetic field (ELF-EMF) exposure in a chronic unpredictable stress (CUS) rat model. The authors report that the combined treatment increased depression-like behavior and neuronal degeneration, reduced GFAP(+) cells in…

The Effect of Time-Dependence of 10 Hz Electromagnetic Field on Spatial Learning and Memory in Rats.

Research RF Safe Research Library Jan 1, 2022

This animal study exposed 40 adult male rats to a 10 Hz (4 mT) extremely low-frequency electromagnetic field for 1 hour daily for either 7 or 30 days. The authors report improved spatial memory after prolonged (30-day) exposure, alongside increased hippocampal BDNF levels. They also note a significant body weight…

The Time-Dependence of Three Different Modes of ELF-EMF Stimulation on LTP at Schaffer Collateral-CA1 Synapses.

Research RF Safe Research Library Jan 1, 2021

This animal ex vivo study tested whether short-term 15 Hz/2 mT ELF-EMF exposure alters LTP at rat hippocampal SC-CA1 synapses. Across sinusoidal, pulsed, and rhythm-pulsed modes, the authors report reduced LTP versus control, with greater inhibition at longer exposure durations (10–60 s). Sinusoidal stimulation…

Exposure to RF-EMF Alters Postsynaptic Structure and Hinders Neurite Outgrowth in Developing Hippocampal Neurons of Early Postnatal Mice.

Research RF Safe Research Library Jan 1, 2021

This animal and primary neuron culture study exposed early postnatal mice to whole-body RF-EMF (SAR 4.0 W/kg) for 5 hours/day from P1 to P28. The authors report reductions in dendritic spine measures (notably mushroom-type spines), decreased glutamate receptor expression in mushroom-type spines, and lower BDNF…

Extremely low frequency electromagnetic fields promote cognitive function and hippocampal neurogenesis of rats with cerebral ischemia.

Research RF Safe Research Library Jan 1, 2021

This animal study evaluated whether ELF-EMF exposure affects recovery-related outcomes after cerebral ischemia in rats. Rats exposed to 50 Hz, 1 mT ELF-EMF for 2 hours daily over 28 days showed better Morris water maze performance than untreated rats. The study also reports increased hippocampal neurogenesis markers…

Exploring the form- And time-dependent effect of low-frequency electromagnetic fields on maintenance of hippocampal long-term potentiation.

Research RF Safe Research Library Jan 1, 2020

This in vitro study developed an MEA-compatible magnetic stimulation device to deliver low-frequency EMFs during hippocampal LTP experiments without interrupting induction. The authors report that sine-wave LF-EMFs applied post-induction or as priming reduced fEPSP slope during LTP maintenance, with stronger effects…

Evaluation of the neuroprotective effects of electromagnetic fields and coenzyme Q on hippocampal injury in mouse.

Research RF Safe Research Library Jan 1, 2019

This animal study tested whether 50 Hz EMF exposure and/or CoQ10 could protect against TMT-induced hippocampal injury in mature female mice. CoQ10 and CoQ10+EMF were associated with improved spatial memory and reduced histological markers of cell death, alongside increased antiapoptotic markers. EMF alone reportedly…

Microwave radiation leading to shrinkage of dendritic spines in hippocampal neurons mediated by SNK-SPAR pathway.

Research RF Safe Research Library Jan 1, 2018

This animal study exposed Wistar rats to microwave radiation (30 mW/cm for 6 minutes, three times per week for six weeks) and assessed cognition, hippocampal dendritic spines, ultrastructure, and SNK-SPAR pathway molecules. The authors report impaired spatial learning and memory, dendritic spine loss/shrinkage, and…

Autophagy mediates the degradation of synaptic vesicles: A potential mechanism of synaptic plasticity injury induced by microwave exposure in rats.

Research RF Safe Research Library Jan 1, 2018

This animal study used an in vivo microwave exposure model (30 mW/cm) and reports reversible neuronal injuries in rats. The authors observed cognitive impairment and synaptic plasticity injury in hippocampal neurons following exposure. Autophagy was activated, and autophagosomes showed increased association with…

From the Cover: 2.45-GHz Microwave Radiation Impairs Hippocampal Learning and Spatial Memory: Involvement of Local Stress Mechanism-Induced Suppression of iGluR/ERK/CREB Signaling.

Research RF Safe Research Library Jan 1, 2018

This mouse study examined low-level 2.45 GHz continuous-wave microwave exposure for 2 hours/day over 15, 30, or 60 days. The authors report impaired learning and spatial memory performance on an 8-arm radial maze after exposure. They also report increased corticosterone and stress/inflammatory-related markers with…

Protective effects of melatonin and omega-3 on the hippocampus and the cerebellum of adult Wistar albino rats exposed to electromagnetic fields.

Research RF Safe Research Library Jan 1, 2017

This rat study examined 900 MHz EMF exposure for 60 minutes per day over 15 days and assessed hippocampal and cerebellar outcomes, behavior, and serum enzyme activity. The EMF-only group showed significant neuronal cell losses in multiple brain regions and worse passive avoidance performance compared with other…

Effects of short and long term electromagnetic fields exposure on the human hippocampus.

Research RF Safe Research Library Jan 1, 2017

This study compared 60 healthy female medical students grouped by self-reported daily mobile phone use by the head (90 min). MRI/MRS analyses found no significant differences in hippocampal volume or in choline, creatine, and N-acetyl aspartate between groups. However, the higher-use group showed poorer performance…

Theta-gamma coupling in hippocampus during working memory deficits induced by low frequency electromagnetic field exposure.

Research RF Safe Research Library Jan 1, 2017

This mouse study examined whether 50 Hz, 1 mT electromagnetic field exposure affects working memory and hippocampal electrophysiology. The authors report reduced Y-maze working memory performance after 3 days of EMF exposure, accompanied by decreased hippocampal firing rates. They also report reduced theta and…

The influence of prenatal 10 GHz microwave radiation exposure on a developing mice brain.

Research RF Safe Research Library Jan 1, 2017

This animal study examined prenatal exposure to 10 GHz microwave radiation starting at gestation day 0.25 or 11.25 until term. At 3 weeks of age, offspring from exposed pregnancies showed reduced brain and body weight and biochemical changes consistent with oxidative stress compared with sham controls. The authors…

Effects of Electromagnetic Radiation from Smartphones on Learning Ability and Hippocampal Progenitor Cell Proliferation in Mice.

Research RF Safe Research Library Jan 1, 2016

This mouse study examined chronic smartphone electromagnetic radiation exposure and its effects on spatial working memory and hippocampal progenitor cell proliferation. The authors report no significant differences in Y-maze spontaneous alternation or BrdU-labeled progenitor proliferation after exposure, but…

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