Lipoic acid inhibits cognitive impairment induced by multiple cell phones in young male rats: role of Sirt1 and Atg7 pathway.
This animal study examined whether lipoic acid modifies cognitive and hippocampal effects in young male rats exposed to EMF emitted from multiple cell phones. The authors report improved learning performance but impaired long-term memory consolidation after EMF exposure, alongside changes in hippocampal neurotransmitter/oxidative stress markers and Sirt1/Atg7 gene expression. Lipoic acid treatment was reported to improve learning and memory and to shift several biochemical and gene-expression measures compared with EMF exposure alone.
Key points
- Forty young male Wistar rats were allocated to control, multiple-cell-phone EMF exposure, or EMF plus lipoic acid treatment groups.
- Cognition was assessed using the Morris water maze at the end of the experimental period.
- EMF-exposed rats showed shorter platform latency by day 5 but reduced consolidation of spatial long-term memory.
- EMF exposure was associated with higher hippocampal Ach, glutamate, and MDA levels.
- EMF exposure was associated with up-regulated hippocampal Sirt1 and Atg7 gene expression.
- Compared with EMF exposure alone, lipoic acid administration was reported to improve learning and memory and modify oxidative stress and gene-expression markers.
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AI-generated summaries may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.
AI-generated summaries may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.
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