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Electromagnetic Field Stimulation Therapy for Alzheimer's Disease.

Research RF Safe Research Library Jan 1, 2024

This review discusses repeated electromagnetic field stimulation (REMFS) as a potential non-invasive therapy for Alzheimer's disease. The abstract describes reported benefits in AD mice, including reduced beta-amyloid, prevention of neuronal death, halted disease progression, and improved memory without edema or…

Variations of the spontaneous electrical activities of the neuronal networks imposed by the exposure of electromagnetic radiations using computational map-based modeling.

Research RF Safe Research Library Jan 1, 2023

This computational neuroscience study models a ring of three coupled Rulkov neurons to examine how electromagnetic induction may change spontaneous neuronal network activity. The abstract reports that magnetic field effects depend on the network’s initial dynamical regime and synaptic strength, including elimination…

A Swine Model of Neural Circuit Electromagnetic Fields: Effects of Immediate Electromagnetic Field Stimulation on Cortical Injury.

Research RF Safe Research Library Jan 1, 2023

This animal study used non-contact induction sensors and a shielded helmet to measure cortical EMF patterns in a Yucatan miniswine before and after traumatic brain injury induced by controlled cortical impact. The authors report that targeted low-frequency EMF stimulation initiated 20 minutes post-injury was…

Immunomodulatory Effect of Electromagnetic Field in the Treatment of Traumatic Brain Injury.

Research RF Safe Research Library Jan 1, 2023

This paper reports a PubMed and Google Scholar-based review of EMF research related to brain pathology, with emphasis on ischemic and traumatic brain injury. It provides a critical overview of the state of the art and describes the authors’ experimental and ongoing studies. The authors conclude that EMF applications…

Consciousness and inward electromagnetic field interactions.

Research RF Safe Research Library Jan 1, 2022

This review discusses longstanding EMF theories of mind/brain integration as a potential explanation for unified conscious experience and aspects of the "hard problem" of consciousness. It notes that EMFs are measurable and that correlates have been reported with changes in consciousness, sensory perception, and…

Bidirectional Effect of Repeated Exposure to Extremely Low-Frequency Electromagnetic Field (50 Hz) of 1 and 7 mT on Oxidative/Antioxidative Status in Rat's Brain: The Prediction for the Vulnerability to Diseases.

Research RF Safe Research Library Jan 1, 2022

This rat study examined repeated 50 Hz ELF-EMF exposure (1 or 7 mT) and measured oxidative stress and antioxidant defense markers in the prefrontal cortex, including responses to a subsequent open-field stressor. The authors report intensity- and repetition-dependent effects: 1 mT produced weak changes and was…

Measuring Electromagnetic Field Activity Generated by Neurons In Vivo by Humans With Thoughts of Repetitive Motor Activities and Emotional Thoughts.

Research RF Safe Research Library Jan 1, 2022

This study describes a helmet-based, non-contact method to continuously measure electromagnetic field activity associated with human brain neuronal activity during thought tasks. Volunteers performed motor movement, motor imagery, and emotional imagery while brain EMF was recorded. The authors report discernible…

Novel Method of Electromagnetic Field Measurements of the Human Brain.

Research RF Safe Research Library Jan 1, 2022

This study describes a lightweight, inexpensive construct using non-contact EMF sensors to measure dynamic electromagnetic fields attributed to the human brain. Measurements in non-clinical volunteers reportedly differed from background recordings and changed during task performance and auditory stimulation. The…

Comparing the Effects of Long-term Exposure to Extremely Low-frequency Electromagnetic Fields With Different Values on Learning, Memory, Anxiety, and β-amyloid Deposition in Adult Rats.

Research RF Safe Research Library Jan 1, 2021

This animal study exposed adult male rats to 50 Hz ELF-EMF at 1, 100, 500, or 2000 μT for 1 hour/day over two months and assessed behavior and brain markers. The authors report increased memory retention (higher step-through latency) alongside increased anxiety-like behavior (reduced open-arm entries), particularly…

Exposure to RF-EMF Alters Postsynaptic Structure and Hinders Neurite Outgrowth in Developing Hippocampal Neurons of Early Postnatal Mice.

Research RF Safe Research Library Jan 1, 2021

This animal and primary neuron culture study exposed early postnatal mice to whole-body RF-EMF (SAR 4.0 W/kg) for 5 hours/day from P1 to P28. The authors report reductions in dendritic spine measures (notably mushroom-type spines), decreased glutamate receptor expression in mushroom-type spines, and lower BDNF…

Extremely low frequency electromagnetic fields promote cognitive function and hippocampal neurogenesis of rats with cerebral ischemia.

Research RF Safe Research Library Jan 1, 2021

This animal study evaluated whether ELF-EMF exposure affects recovery-related outcomes after cerebral ischemia in rats. Rats exposed to 50 Hz, 1 mT ELF-EMF for 2 hours daily over 28 days showed better Morris water maze performance than untreated rats. The study also reports increased hippocampal neurogenesis markers…

Exploring the form- And time-dependent effect of low-frequency electromagnetic fields on maintenance of hippocampal long-term potentiation.

Research RF Safe Research Library Jan 1, 2020

This in vitro study developed an MEA-compatible magnetic stimulation device to deliver low-frequency EMFs during hippocampal LTP experiments without interrupting induction. The authors report that sine-wave LF-EMFs applied post-induction or as priming reduced fEPSP slope during LTP maintenance, with stronger effects…

Early exposure to radiofrequency electromagnetic fields at 1850 MHz affects auditory circuits in early postnatal mice.

Research RF Safe Research Library Jan 1, 2019

This animal study examined early postnatal mice after exposure to 1850 MHz RF-EMF and measured synaptic activity in brainstem auditory circuitry. The abstract reports increased spontaneous postsynaptic current frequency and amplitude in MNTB principal cells, with accompanying presynaptic changes in the calyx of Held…

Effects of 1800 MHz RF-EMF exposure on DNA damage and cellular functions in primary cultured neurogenic cells.

Research RF Safe Research Library Jan 1, 2018

This in vitro study exposed primary cultured astrocytes, microglia, and cortical neurons to 1800 MHz RF-EMF at 4.0 W/kg SAR to assess DNA damage and cellular functions. The authors report no significant induction of γH2AX foci and no significant changes in cytokine secretion or dendrite/synapse morphological…

Microwave radiation leading to shrinkage of dendritic spines in hippocampal neurons mediated by SNK-SPAR pathway.

Research RF Safe Research Library Jan 1, 2018

This animal study exposed Wistar rats to microwave radiation (30 mW/cm for 6 minutes, three times per week for six weeks) and assessed cognition, hippocampal dendritic spines, ultrastructure, and SNK-SPAR pathway molecules. The authors report impaired spatial learning and memory, dendritic spine loss/shrinkage, and…

Autophagy mediates the degradation of synaptic vesicles: A potential mechanism of synaptic plasticity injury induced by microwave exposure in rats.

Research RF Safe Research Library Jan 1, 2018

This animal study used an in vivo microwave exposure model (30 mW/cm) and reports reversible neuronal injuries in rats. The authors observed cognitive impairment and synaptic plasticity injury in hippocampal neurons following exposure. Autophagy was activated, and autophagosomes showed increased association with…

Age-dependent effect of long-term microwave radiation on postnatal neurogenesis in rats: morphological and behavioral study.

Research RF Safe Research Library Jan 1, 2018

This animal study examined pulsed-wave 2.45 GHz microwave radiation exposure (1 or 3 hours daily for 3 weeks) in adult and juvenile rats and assessed neurogenesis-related markers in the rostral migratory stream. The authors report reduced cell proliferation in adults and longer-lasting effects on cell death after…

Weak electric fields detectability in a noisy neural network.

Research RF Safe Research Library Jan 1, 2017

This modeling study examines how a noisy spiking neural network detects a weak applied electric field using an Izhikevich neuron framework with excitatory/inhibitory neurons and conduction delays. The authors report stochastic resonance driven by white noise that enhances detectability, and that this effect largely…

Influence of the on-line ELF-EMF stimulation on the electrophysiological properties of the rat hippocampal CA1 neurons in vitro.

Research RF Safe Research Library Jan 1, 2017

This paper describes an on-line ELF magnetic stimulation setup and evaluates coil field distribution using COMSOL simulations alongside physical measurements. The authors report that modeled and measured magnetic flux densities were similar, and that stimulation induced sodium channel currents and fEPSPs in rat…

The expression of pluripotency and neuronal differentiation markers under the influence of electromagnetic field and nitric oxide.

Research RF Safe Research Library Jan 1, 2017

This in vitro study examined how 50 Hz low-frequency EMF and a nitric oxide donor (Deta-NO) affect stemness and neuronal differentiation markers in rat bone marrow mesenchymal stem cells. The authors report that high NO (1 mM) combined with EMF reduced stemness markers and increased neuronal differentiation markers,…

Effects of radiofrequency exposure emitted from a GSM mobile phone on proliferation, differentiation, and apoptosis of neural stem cells.

Research RF Safe Research Library Jan 1, 2017

This in vitro study evaluated adult murine neural stem cells exposed to GSM 900-MHz radiofrequency emissions from a mobile phone across different exposure durations. The authors report significant decreases in neurosphere number/size and neuronal differentiation with increasing exposure duration. They report no…

Theta-gamma coupling in hippocampus during working memory deficits induced by low frequency electromagnetic field exposure.

Research RF Safe Research Library Jan 1, 2017

This mouse study examined whether 50 Hz, 1 mT electromagnetic field exposure affects working memory and hippocampal electrophysiology. The authors report reduced Y-maze working memory performance after 3 days of EMF exposure, accompanied by decreased hippocampal firing rates. They also report reduced theta and…

A Route to Chaotic Behavior of Single Neuron Exposed to External Electromagnetic Radiation.

Research RF Safe Research Library Jan 1, 2017

This computational study investigates nonlinear membrane-potential dynamics in a Fitzhugh-Nagumo single-neuron model that includes an external electromagnetic radiation term. The authors report that increasing the frequency of an external transmembrane current leads to mode selection among periodic, quasi-periodic,…

Effects of extremely low-frequency electric fields at different intensities and exposure durations on mismatch negativity

Research RF Safe Research Library Jul 11, 2014

This rat study examined whether 50-Hz extremely low-frequency electric fields at 12 or 18 kV/m for 2 or 4 weeks affect mismatch negativity (MMN) and markers of oxidative damage/apoptosis in brain tissue. MMN amplitude was reported to be significantly reduced only in the 18 kV/m, 4-week exposure group versus the…

An ephaptic transmission model of CA3 pyramidal cells: an investigation into electric field effects.

Research RF Safe Research Library Jan 1, 2014

This paper presents a two-compartment computational model of CA3 pyramidal neurons to investigate how extracellular electric fields influence neuronal behavior via ephaptic transmission. The model is matched to subthreshold experimental responses at rest and used to analyze how DC and sinusoidal fields affect…

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