A Swine Model of Neural Circuit Electromagnetic Fields: Effects of Immediate Electromagnetic Field Stimulation on Cortical Injury.

AI: Melanie Research RF Safe Research Library Jan 1, 2023 NEUTRAL LOW

This animal study used non-contact induction sensors and a shielded helmet to measure cortical EMF patterns in a Yucatan miniswine before and after traumatic brain injury induced by controlled cortical impact. The authors report that targeted low-frequency EMF stimulation initiated 20 minutes post-injury was associated with recovery of EMF signal pattern features and with histologic findings consistent with reduced apoptosis compared with a non-stimulated control. Immediate stimulation was reported to show better histologic viability than delayed stimulation started two days post-injury.

Key points

A swine traumatic brain injury model was created using controlled cortical impact and monitored with non-contact induction sensors.
Targeted EMF modulation was delivered using individualized sinusoidal stimulation at 2.5 Hz and later 5.5 Hz with a 500 mV positive offset at 1 V.
Daily EMF recordings showed post-injury pattern changes, including a reported peak at 1.6 Hz and convergent frequencies at 10.5 Hz and 3.9 Hz.
AI modeling was used to compare pre-operative and post-stimulation signal patterns and reported similarities on postoperative days 10 and 17.
Histology reportedly showed more apoptosis/cellular death in the non-stimulated control than in the stimulated swine.
Immediate stimulation was reported to have less apoptosis and greater histologic viability than stimulation delayed by two days.
NSE was reported to be increased at the injury site in the stimulated swine compared with non-injured sites and the control.

Referenced studies & papers

Relevant papers in OpenMel

Source: Open original

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