Non-Ionizing Radiation for Cardiac Human Amniotic Mesenchymal Stromal Cell Commitment: A Physical Strategy in Regenerative Medicine.

AI: Melanie Research RF Safe Research Library Jan 1, 2018 NEUTRAL LOW

This in vitro study exposed human amniotic mesenchymal stromal cells to an ELF-EMF stimulus (7 Hz, 2.5 µT) and compared responses with a nitric oxide chemical treatment. The authors report reduced cell proliferation with no change in metabolic activity, vitality, or apoptosis after ELF-EMF exposure. They also report increased cardiac and angiogenic differentiation marker expression (mRNA and protein), interpreting this as ELF-EMF-triggered cardiac commitment and concurrent cardiac/angiogenic commitment under the physical stimulus.

Key points

Human amniotic mesenchymal stromal cells were isolated, characterized, and exposed in vitro to ELF-EMF and to nitric oxide treatment.
The ELF-EMF exposure parameters reported were 7 Hz and 2.5 µT.
ELF-EMF exposure was associated with decreased cell proliferation in the abstract.
No change was reported for metabolic activity, cell vitality, or apoptotic rate under ELF-EMF exposure.
Cardiac and angiogenic differentiation marker mRNA expression increased in exposed cells and was reported as confirmed at the protein level.
The authors interpret the marker changes as evidence that ELF-EMF can trigger cardiac commitment of hAMSCs.
The authors report that only the physical stimulus induced both cardiac and angiogenic commitments concurrently in their conditions.

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