Effect of electromagnetic field radiation on transcriptomic profile and DNA methylation level in pig conceptuses during the peri-implantation period
This in vitro study exposed pig conceptuses (days 15–16 of pregnancy) to 50 Hz ELF-EMF for 2 hours and assessed transcriptomic and DNA methylation changes. The authors report altered expression of 21 protein-coding transcripts and an approximately 16-fold increase in genomic DNA methylation, with promoter methylation changes in several named genes. They conclude ELF-EMF interacts with gene expression and DNA methylation processes during early development and call for further safety research.
Key points
- Pig conceptuses collected on days 15–16 of pregnancy were exposed in vitro to 50 Hz ELF-EMF for 2 hours.
- ELF-EMF exposure was reported to modify expression of 21 protein-coding transcripts.
- The study reports GO and KEGG pathway annotations associated with the differentially expressed genes.
- Genomic DNA methylation levels were reported to increase by approximately 16-fold after ELF-EMF exposure.
- Promoter-region DNA methylation changes were detected for APOM, HSD17B2, FGG, and SLC34A1.
- The authors identified 116 predicted SNV substitutions within RNA editing sites following ELF-EMF treatment.
- The paper frames the findings as significant molecular changes during a critical developmental stage and calls for further research on safety and biological impact.
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AI-generated summaries may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.
AI-generated summaries may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.
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