Causal relationship between the duration of mobile phone use and risk of stroke: A Mendelian randomization study
This Mendelian randomization study assessed whether duration of mobile phone use is causally related to stroke outcomes using GWAS-derived SNP instruments. The inverse-variance weighted analysis reported a significant increased risk for large artery atherosclerosis (LAAS) with longer mobile phone use duration, while other stroke outcomes showed no significant associations. Sensitivity analyses (including MR-Egger and heterogeneity/asymmetry tests) were reported as suggesting the LAAS finding was robust.
Key points
- Mendelian randomization was used to evaluate duration of mobile phone use as an exposure and multiple stroke outcomes as endpoints.
- Ninety SNPs from GWAS datasets were used as instrumental variables (as described in the abstract).
- Inverse-variance weighted analysis reported an increased risk of large artery atherosclerosis (LAAS) with longer mobile phone use duration.
- No significant associations were reported for overall stroke, intracerebral hemorrhage, ischemic stroke, cardioembolic infarction, or small-vessel disease.
- MR-Egger regression was reported to suggest bias from multidimensionality was unlikely.
- Heterogeneity/asymmetry tests were reported as indicating robust findings for the main result.
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AI-generated summaries may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.
AI-generated summaries may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.
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