Causal relationship between duration of mobile phone use and risk of aneurysmal subarachnoid hemorrhage: A 2-sample Mendelian randomization analysis
This two-sample Mendelian randomization study examined whether duration of mobile phone use is causally related to aneurysmal subarachnoid hemorrhage using large European GWAS datasets. The primary MR analysis reported that excessive duration of mobile phone use was associated with higher aSAH risk, and sensitivity analyses were described as supportive. The authors conclude the findings have potential clinical, public health, and policy implications.
Key points
- The study used a two-sample Mendelian randomization design to assess causality between mobile phone use duration and aSAH risk.
- Twenty-three SNPs were used as instrumental variables for duration of mobile phone use.
- GWAS outcome data included 7,480 aSAH cases and 329,679 controls in European populations.
- The primary MR analysis reported increased aSAH risk with excessive duration of mobile phone use (OR 2.20, 95% CI 1.26β3.83).
- MR-Egger results were presented as suggesting directional pleiotropy was unlikely to explain the findings.
- The weighted median method also supported an increased risk estimate.
- The abstract reports no heterogeneity or asymmetry, described as supporting robustness.
Referenced studies & papers
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AI-generated summaries may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.
AI-generated summaries may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.
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