Anticancer and antibacterial potentials induced post short-term exposure to electromagnetic field and silver nanoparticles and related pathological and genetic alterations: in vitro study.

Key points

• The study is an in vitro assessment of ELF-EMF and silver nanoparticles (AgNPs) as antibacterial and anticancer agents.
• Bacterial outcomes were measured using viable count reduction in K. pneumoniae and S. aureus.
• The authors report stronger antibacterial effects for K. pneumoniae than for S. aureus, with time-dependent reductions.
• A combined condition (ELF-EMF + 10 µM/ml AgNPs for 2 h) was reported to achieve 100% inhibition for K. pneumoniae.
• Apoptosis in MCF-7 cells was assessed by Annexin V-FITC and cell-cycle analysis and was reported to increase after ELF-EMF or AgNPs.
• The apoptotic effect was reported to be intensified under combined ELF-EMF and AgNP exposure, with increased Pre G1 fraction versus control.
• Cell-cycle effects differed by agent, with S phase arrest reported for AgNPs and G2/M accumulation reported for EMF.
• Gene expression changes included up-regulation of p53, iNOS, and NF-kB and down-regulation of Bcl-2 and miRNA-125b after treatment.

Referenced studies & papers

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