This study introduces a multi-scale electrokinetic model to characterize electrical impulses and ionic current propagation along microtubules, incorporating atomistic protein details and biological environments. It emphasizes nanopore-mediated coupling between microtubule surfaces as a key mechanism enabling luminal currents, energy transfer, amplification, and oscillatory dynamics. The authors report pharmacological inhibition experiments (Taxol and Gd3+) supporting the interpretation that nanopores function as active nanogates contributing to transistor-like behavior.