Archive
3 postsFilters: tag: dna-repair Clear
Impact of in vitro exposure to 5G-modulated 3.5 GHz fields on oxidative stress and DNA repair in skin cells
This in vitro study tested whether 5G-modulated 3.5 GHz RF-EMF exposure affects oxidative stress and DNA repair in human skin cells. Under acute exposure conditions (up to 24–48h) at SARs up to 4 W/kg, the authors report no significant changes in ROS markers, no adaptive response to oxidative challenge, and no impairment of UV-B–related CPD repair via nucleotide excision repair. The authors note that acute in vitro results may not directly generalize to chronic or real-life exposures.
Skin Fibroblasts from Individuals Self-Diagnosed as Electrosensitive Reveal Two Distinct Subsets with Delayed Nucleoshuttling of the ATM Protein in Common
This study reports on 26 adults self-diagnosed with electromagnetic hypersensitivity (EHS) who provided skin biopsies to generate primary fibroblast lines. The authors describe two EHS subsets based on questionnaire and DNA damage-related measures, and report delayed ATM nucleoshuttling after X-ray exposure in all samples, interpreted as impaired DNA repair signaling. They propose a molecular model linking EHS to ATM pathway dysfunction and suggest this could relate to increased cancer risk or accelerated aging.
Electromagnetic fields and DNA damage
This review discusses the comet assay and summarizes research on non-ionizing EMF exposure and DNA/chromosomal damage. It describes both positive and negative findings across studies, noting no consistent overall pattern for radiofrequency radiation (RFR). The authors nonetheless conclude that under certain exposure conditions RFR appears genotoxic and may affect DNA damage and repair, with evidence discussed as most applicable to exposures typical of cell phone use.