The effects of electrical stimulation on neurons and glia of the central nervous system
Research
RF Safe Research Library
Jan 1, 2025
This review synthesizes evidence on how direct current and alternating current electrical stimulation affect neurons and glia in the central nervous system, spanning basic research and clinical translation. It reports polarity- and parameter-dependent effects on axonal growth, along with immunomodulatory glial…
Effect of the radiation emitted from a cell phone on T lymphocytes in mice
Research
RF Safe Research Library
Jan 1, 2025
This mouse study examined whether cell phone radiation affects T lymphocytes over 2–8 weeks of exposure. CD4 and CD8 subset percentages were similar across groups, but after more than six weeks, exposed groups showed increased T-cell apoptosis and reduced transformation rates compared with shams. The study also…
Extremely low-frequency electromagnetic field (ELF-EMF) induced alterations in gene expression and cytokine secretion in clear cell renal carcinoma cells.
Research
RF Safe Research Library
Jan 1, 2024
This in vitro study exposed three ccRCC cell lines and a healthy kidney cell line (HEK293) to 50 Hz ELF-EMF at 4.5 mT for 30 minutes daily over 5 days. The authors report exposure-associated changes in expression of several genes (names not fully visible in the abstract), with differences between primary…
Extremely Low-Frequency Electromagnetic Fields Increase Cytokines in Human Hair Follicles through Wnt/β-Catenin Signaling.
Research
RF Safe Research Library
Jan 1, 2022
This in vitro/ex vivo study examined extremely low-frequency EMF exposure in human hair bulb spheroids and hair follicle organ cultures. The authors report no toxicity and increased expression of anagen-related markers and multiple cytokines/growth factors at 5–20 G, with 10 G for 60 minutes associated with increased…
Evaluation of Cell Migration and Cytokines Expression Changes under the Radiofrequency Electromagnetic Field on Wound Healing In Vitro Model.
Research
RF Safe Research Library
Jan 1, 2022
This in vitro study evaluated whether radiofrequency electromagnetic field (RF-EMF) exposure could influence wound-healing-related processes. The authors report increased keratinocyte migration and changes in expression of wound-healing genes, including MMPs, TIMPs, and pro/anti-inflammatory cytokines. The abstract…
Necroptosis triggered by ROS accumulation and Ca overload, partly explains the inflammatory responses and anti-cancer effects associated with 1Hz, 100 mT ELF-MF in vivo.
Research
RF Safe Research Library
Jan 1, 2021
This animal and in vitro study examined ELF magnetic field exposure in a mouse breast tumor model and a breast cancer cell line. The authors report tumor growth suppression and reduced expression of Ki-67, CD31, VEGFR2, and MMP-9 after exposure. They also report increased IFN-γ and TNF-α and increased…
Increase in Blood Levels of Growth Factors Involved in the Neuroplasticity Process by Using an Extremely Low Frequency Electromagnetic Field in Post-stroke Patients.
Research
RF Safe Research Library
Jan 1, 2018
This study evaluated whether adding extremely low-frequency electromagnetic field (ELF-EMF) therapy to standard post-stroke rehabilitation affects biomarkers of neuroplasticity and functional recovery. Forty-eight patients completed the same rehabilitation program, with the study group additionally receiving 10…
Fas/FasL pathway and cytokines in keratinocytes in atopic dermatitis - Manipulation by the electromagnetic field.
Research
RF Safe Research Library
Jan 1, 2018
This in vitro study exposed keratinocytes from atopic dermatitis patients and healthy controls, plus two keratinocyte cell lines, to a 900 MHz electromagnetic field for 60 minutes. AD-derived keratinocytes showed higher Fas/FasL signaling markers and increased secretion of multiple cytokines versus controls. EMF…
Effects of 1800 MHz RF-EMF exposure on DNA damage and cellular functions in primary cultured neurogenic cells.
Research
RF Safe Research Library
Jan 1, 2018
This in vitro study exposed primary cultured astrocytes, microglia, and cortical neurons to 1800 MHz RF-EMF at 4.0 W/kg SAR to assess DNA damage and cellular functions. The authors report no significant induction of γH2AX foci and no significant changes in cytokine secretion or dendrite/synapse morphological…
The effects of radio-frequency electromagnetic fields on T cell function during development
Research
RF Safe Research Library
Jan 1, 2015
This animal study exposed developing Sprague Dawley rats to 2.14 GHz W-CDMA RF-EMF at a whole-body SAR of 0.2 W/kg for 9 weeks (20 h/day). No differences were reported in multiple T cell population measures across blood, spleen, and thymus. Some Th1/Th2-related genes were upregulated (notably in thymus), but serum…
Microwave radiation induced oxidative stress, cognitive impairment and inflammation in brain of Fischer rats.
Research
RF Safe Research Library
Jan 1, 2012
This animal study exposed male Fischer-344 rats to 900 MHz or 1800 MHz microwave radiation for 30 days (2 h/day) and compared outcomes to sham exposure. The authors report significant cognitive impairment along with increased oxidative stress in brain tissue in exposed rats. They also report increased inflammatory…
Low-frequency electromagnetic fields do not alter responses of inflammatory genes and proteins in human monocytes and immune cell lines.
Research
RF Safe Research Library
Jan 1, 2012
This in vitro study examined whether low-frequency electromagnetic fields (a complex multiple waveform field and a 50 Hz sine wave) alter inflammatory gene and protein responses in human immune cells. Across time course experiments in THP-1 cells and primary monocytes/macrophages, the authors report no significant…