This in vitro study tested whether 1800 MHz RF-EMF modifies chemically induced DNA damage in mouse embryonic fibroblasts under non-thermal exposure conditions. RF-EMF alone did not produce detectable DNA damage and did not significantly enhance damage from hydrogen peroxide, 4NQO, or cadmium. In contrast, co-exposure with hexavalent chromium (Cr(VI)) was reported to synergistically increase DNA damage, suggesting a selective co-genotoxic interaction under specific chemical conditions.

An RF Safe post argues that a 2018 review on EMF-related oxidative stress supports a mechanistic chain from radiofrequency (RF-EMF) exposure to mitochondrial reactive oxygen species (ROS) increases and downstream inflammation, emphasizing non-thermal exposures. It highlights the review’s focus on mitochondrial electron transport chain complexes I and III and discusses calcium signaling disruptions, then connects these to the site’s “Ion Timing Fidelity” model involving voltage-gated channel timing (S4 segment). The post also cites in-vitro human sperm research and other reviews as consistent with mitochondrial oxidative stress effects, while noting gaps in standardized human studies.