This animal proof-of-concept study describes an engineered nanoparticle–cell interface (EMPOWER) enabling wireless regulation of transgene expression using a 1-kHz magnetic field. Chitosan-coated multiferroic nanoparticles reportedly generate intracellular ROS that activates KEAP1/NRF2 biosensors connected to ROS-responsive promoters. In a mouse model of type 1 diabetes, implanted engineered cells expressing an EMPOWER-controlled insulin system reportedly normalized blood glucose in response to a weak magnetic field.

This in vitro study reports that a static magnetic field (SMF) combined with paramagnetic calcium-polypyrrole nanoparticles (Ca-PPy) markedly increases bactericidal activity against E. coli and S. aureus. The authors attribute the enhanced killing to increased reactive oxygen species generation and associated membrane disruption, with computational analysis suggesting altered radical-pair transitions under magnetic fields. The abstract frames SMF as potentially biocompatible and useful for bactericidal applications, while also noting broader biological impacts of electromagnetic fields.