This RF Safe article argues that “non-native” electromagnetic fields (from power systems, radio, and mobile/5G signals) can disrupt the timing of voltage-gated ion channel activity in immune cells, leading to altered immune signaling, mitochondrial stress, and chronic inflammation. It links these proposed mechanisms to increases in autoimmune-type and immune-driven diseases over time, and cites a mix of reviews, cell studies, animal studies, and rodent bioassays as supportive evidence. The piece frames EMF risk as driven by signal timing/patterning rather than heating, and calls for regulation and engineering changes to address these effects.

RF Safe argues that radiofrequency radiation (especially pulsed or modulated signals with low-frequency components) can alter local membrane potentials at nanometer scales where voltage-gated ion channel S4 sensors operate. It claims these shifts could change ion channel gating in immune cells, altering calcium and proton signaling, increasing oxidative stress, and promoting innate immune activation that may contribute to autoimmune-like inflammation. The piece presents a mechanistic causal chain and highlights heart and nerve tissue as potentially more susceptible due to high ion-channel density and mitochondrial content, but does not present new study data in the provided text.

RF Safe publishes a mechanistic white-paper-style post arguing that pulsed/low-frequency components of RF exposure could introduce “phase noise” into voltage-gated ion channel (VGIC) voltage sensors (S4), degrading the timing of membrane potentials and calcium (Ca²⁺) oscillations that immune cells use for activation and tolerance decisions. The post claims such timing disruption could mis-set immune thresholds, promote inflammation, and trigger mitochondrial ROS and mtDNA release that sustains a feed-forward inflammatory loop. It frames reported tumor patterns in animal bioassays (e.g., cardiac schwannomas, gliomas) as consistent with this proposed “timing-fidelity” mechanism, while acknowledging competing views on whether RF at current limits can couple to VGICs.