Sinusoidal Extremely Low-Frequency Electromagnetic Stimulation (ELF-EMS) Promotes Angiogenesis In Vitro.
Research
RF Safe Research Library
Jan 1, 2025
This in vitro/in ovo study examined whether extremely low-frequency electromagnetic stimulation (ELF-EMS; 13.5 mT at 10 and 60 Hz) activates angiogenic processes under homeostatic conditions. In human microvascular endothelial cells, ELF-EMS increased proliferation, migration/transmigration, and tube formation, with…
Effects of pulsed electromagnetic fields and N-acetylcysteine on transplantation of vitrified mouse ovarian tissue.
Research
RF Safe Research Library
Jan 1, 2023
This experimental mouse study tested whether N-acetylcysteine (NAC), pulsed electromagnetic fields (PEMF), or their combination improves outcomes after transplantation of vitrified ovarian tissue. The abstract reports increased follicle numbers and enhanced vascularization in NAC, PEMF, and NAC+PEMF groups, along…
Magnetofection of miR-21 promoted by electromagnetic field and iron oxide nanoparticles via the p38 MAPK pathway contributes to osteogenesis and angiogenesis for intervertebral fusion.
Research
RF Safe Research Library
Jan 1, 2023
This study describes a magnetofection system using electromagnetic field (EMF) co-stimulation with iron oxide nanoparticles (IONPs) to deliver miR-21. The authors report increased transfection efficiency and promotion of osteogenesis and angiogenesis in BMSCs and HUVECs, with downstream application to…
Sinusoidal electromagnetic fields accelerate bone regeneration by boosting the multifunctionality of bone marrow mesenchymal stem cells.
Research
RF Safe Research Library
Jan 1, 2021
This in vitro and rat study evaluated sinusoidal electromagnetic field (EMF) treatment of bone marrow mesenchymal stem cells (BMSCs) seeded on 3D-printed scaffolds for repairing critical-sized calvarial defects. The authors report that EMF-treated cell scaffolds accelerated bone defect repair in rats.…
The combinatory effect of sinusoidal electromagnetic field and VEGF promotes osteogenesis and angiogenesis of mesenchymal stem cell-laden PCL/HA implants in a rat subcritical cranial defect.
Research
RF Safe Research Library
Jan 1, 2019
This animal and in vitro study evaluated sinusoidal electromagnetic field (SEMF) exposure combined with VEGF in rat mesenchymal stem cells and in a rat cranial defect model using rBMSC-laden PCL/HA scaffolds. The authors report increased osteogenic and endothelial marker expression with SEMF and VEGF, with a slight…
Ca2+ and CACNA1H mediate targeted suppression of breast cancer brain metastasis by AM RF EMF
Research
RF Safe Research Library
Jan 1, 2019
This study describes a therapeutic use of athermal, amplitude-modulated RF EMF (27.12 MHz) at breast cancer-specific frequencies to target breast cancer brain metastases. The abstract reports tumor growth suppression in animal models and durable regression in one patient with triple negative breast cancer brain…