Risk factors for suboptimal target attainment of commonly used ß-lactam antibiotics in older adults: a prospective cohort study.
Research
RF Safe Research Library
Jan 1, 2026
This prospective observational pharmacokinetic study in geriatric inpatients (≥75 years) assessed whether standard IV dosing of amoxicillin-clavulanate and piperacillin-tazobactam achieved a 100% fT>MIC target. Target attainment was lower for amoxicillin-clavulanate than for piperacillin-tazobactam in this cohort.…
Synthesis, biological evaluation, molecular docking, molecular dynamics simulation, and ADME studies of novel carbazole-aniline hybrids as cytotoxic agents.
Research
RF Safe Research Library
Jan 1, 2026
This study reports the design and synthesis of seven carbazole-aniline hybrids and evaluates their cytotoxicity in breast (MCF-7) and colon (SW480) cancer cell lines. Compound 5e was identified as the most potent in vitro candidate and was supported by docking and molecular dynamics results suggesting binding to…
Necroptosis triggered by ROS accumulation and Ca overload, partly explains the inflammatory responses and anti-cancer effects associated with 1Hz, 100 mT ELF-MF in vivo.
Research
RF Safe Research Library
Jan 1, 2021
This animal and in vitro study examined ELF magnetic field exposure in a mouse breast tumor model and a breast cancer cell line. The authors report tumor growth suppression and reduced expression of Ki-67, CD31, VEGFR2, and MMP-9 after exposure. They also report increased IFN-γ and TNF-α and increased…
Precision knockdown of EGFR gene expression using radio frequency electromagnetic energy.
Research
RF Safe Research Library
Jan 1, 2017
This study reports a technology that records a specific radiofrequency electromagnetic energy signal associated with EGFR siRNA and applies it to cells. The abstract describes reductions in EGFR mRNA and protein expression versus controls, with specificity assessed using RNA microarray and antibody dot blot array. It…
[A preliminary study on role of acid sphingomyelinase in receptor clustering induced by 50-Hz magnetic fields].
Research
RF Safe Research Library
Jan 1, 2009
This in vitro study exposed human amnion (FL) cells to a 50-Hz sinusoidal magnetic field (0.4 mT) for 15 minutes and assessed epidermal growth factor receptor (EGFR) clustering. The authors report that magnetic field exposure induced EGFR clustering, and that this effect was blocked by imipramine, an acid…
Noninvasive radiofrequency field-induced hyperthermic cytotoxicity in human cancer cells using cetuximab-targeted gold nanoparticles.
Research
RF Safe Research Library
Jan 1, 2008
This in vitro study reports that shortwave (MHz-range) RF exposure can induce strong cytotoxicity in EGFR-overexpressing human cancer cells when those cells have internalized cetuximab-targeted gold nanoparticles. Control nanoparticles showed minimal uptake and substantially lower cytotoxicity under RF exposure. An…