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Electromagnetic fields and oxidative stress: The link to the development of cancer, neurological diseases, and behavioral disorders

Research RF Safe Research Library Jan 1, 2025

This review discusses epidemiological and mechanistic reports linking EMF exposure with oxidative stress and disease risk, and introduces an Electromagnetic Pathogenesis (EMP) conceptual model. The model proposes that non-ionizing EMFs increase mitochondrial electron leakage via electron tunneling, raising free radical production and oxidative stress. The authors argue oxidative stress is a primary mechanism connecting EMF exposure to cancer, cardiovascular, neurodevelopmental/neurodegenerative diseases, and behavioral/reproductive effects, and suggest reducing exposure may lower risk.

Transition Pathways Towards Electromagnetic Sustainability in the Built and Lived Environment

Research RF Safe Research Library Jan 1, 2025

This paper discusses electromagnetic (EM) fields as an environmental health and sustainability issue in the built and lived environment, particularly with expanding ICT and energy systems. It reports conducting a literature review and EM field audits in three locations across two cities in Canada and the UK to examine exposure trends and review major safety guidelines. The authors propose transition pathways toward “electromagnetic sustainability,” emphasizing planning, exposure reduction, and risk governance.

The Influence of Mobile Technologies on the Quality of Sleep

Research RF Safe Research Library Jan 1, 2025

This study assessed whether sleeping with versus without a mobile phone (two-week intervals) affects sleep in medical students, using smartwatch-based monitoring. It reports no statistically significant differences in sleep quality or time spent in wakefulness, REM, light, or deep sleep between conditions. The authors report a statistically significant effect on minimum and average blood oxygen saturation during sleep and call for further research on nightly RF-EMF exposure.

Effects of Simultaneous In-Vitro Exposure to 5G-Modulated 3.5 GHz and GSM-Modulated 1.8 GHz Radio-Frequency Electromagnetic Fields on Neuronal Network Electrical Activity and Cellular Stress in Skin Fibroblast Cells

Research RF Safe Research Library Jan 1, 2025

This in-vitro study exposed primary cortical neurons and human immortalized skin fibroblasts to simultaneous 5G-modulated 3.5 GHz and GSM-modulated 1.8 GHz RF-EMF at SARs of 1 or 4 W/kg. It reports no significant changes in neuronal network firing/bursting activity and no alteration of mitochondrial ROS in fibroblasts. Stress-related signaling readouts showed only minor, threshold-level variations without a consistent pattern, and no HSF1 activation was observed. Overall, the authors conclude there is no strong evidence of biological effects under these exposure conditions.

Male Reproductive and Cellular Damage After Prenatal 3.5 GHz Radiation Exposure: One-Year Postnatal Effects

Research RF Safe Research Library Jan 1, 2025

This animal study examined whether prenatal exposure to 3.5 GHz radiofrequency radiation (2 hours/day) affects male reproductive outcomes later in life. Male rat offspring assessed at 12 months showed multiple adverse testicular and cellular findings in exposed groups versus sham controls, including impaired spermatogenesis markers, increased abnormal sperm morphology, increased DNA damage, and increased apoptosis, with full-gestation exposure generally most pronounced. The authors interpret the results as evidence of persistent reproductive toxicity from prenatal exposure and call for further mechanistic work and precautionary actions.

Synergistic Effects of 2600 MHz Radiofrequency Exposure and Indomethacin on Oxidative Stress and Gastric Mucosal Injury in Rats

Research RF Safe Research Library Jan 1, 2025

This rat study tested whether 2600 MHz radiofrequency field exposure interacts with indomethacin to affect gastric tissue. Both exposures alone were reported to increase oxidative stress and reduce antioxidant markers in the stomach. Co-exposure was reported to intensify oxidative stress, apoptosis, and histological gastric mucosal injury compared with either factor alone, consistent with a synergistic detrimental effect in this model.

Effect of Electromagnetic Field on Oral Tissues: A Narrative Review

Research RF Safe Research Library Jan 1, 2025

This narrative review explores potential links between EMF exposure, metallic or mixed-metal dental restorations, and reported systemic and neurological symptoms despite normal diagnostic findings. It discusses hypothesized quantum-biological mechanisms (including spin dynamics and radical-pair mechanisms) that could mediate interactions between EMFs and dental metals. The authors conclude that the complexity of these interactions warrants more rigorous research and emphasize that a possible health-risk link should not be ignored.

Electromagnetic Field Stimulation Effects on Intrinsically Disordered Proteins and Their Role in Aging and Neurodegeneration

Research RF Safe Research Library Jan 1, 2025

This review discusses preclinical studies suggesting non-ionizing EMF exposures can produce beneficial biological effects, while noting ongoing controversy about mechanisms. It reports evidence of EMF-associated conformational changes in intrinsically disordered proteins relevant to neurodegeneration and describes RF exposure conditions that activate proteostasis and autophagy in cell and animal models. The authors propose a quantum-biophysical framework involving the water-protein interface and suggest potential human applications within regulatory safety thresholds.

Visualizing radiofrequency electromagnetic field exposure through Voronoi-based maps

Research RF Safe Research Library Jan 1, 2025

This exposure-assessment study proposes a Voronoi-diagram approach to visualize RF-EMF exposure across a city using personal exposimeter measurements of RMS electric field at seed points. Most mapped areas corresponded to about 1.9 V/m, with a maximum reported value of 11.4 V/m, all below the cited ICNIRP guideline level. The authors conclude the method is useful for communicating spatial variability, while also noting broader literature discussing potential health risks from EMF exposure.

Empowering the Serbian EMF RATEL System for Monitoring RF-EMF Through Drive Test

Research RF Safe Research Library Jan 1, 2025

This engineering/monitoring paper describes enhancements to the Serbian EMF RATEL system, which has continuously monitored RF-EMF since 2017, by adding drive test functionality to improve spatial coverage. The authors report preliminary quantitative drive test measurements and validation of the upgraded approach. The work emphasizes that characterizing spatial and temporal RF-EMF patterns can support exposure assessment relevant to public health risk evaluation.

Thermal and SAR-Based Limits for Human Skin Exposed to Terahertz Radiation

Research RF Safe Research Library Jan 1, 2025

This conference paper uses COMSOL Multiphysics simulations to evaluate thermal and SAR-based exposure limits for modeled human skin exposed to terahertz radiation (0.1–5 THz). The authors report negligible temperature increases at power densities consistent with keeping SAR below 1.6 W/kg, but note that higher power densities can yield minimal heating while producing SAR values above recognized safety thresholds. They conclude that existing sub-THz standards are not directly transferable to the full THz band and call for updated guidelines, especially for prolonged exposure.

Prolonged 3.5 GHz and 24 GHz RF-EMF Exposure Alters Testicular Immune Balance, Apoptotic Gene Expression, and Sperm Function in Rats

Research RF Safe Research Library Jan 1, 2025

This rat study examined 60-day RF-EMF exposure at 3.5 GHz and 24 GHz for 1 or 7 hours per day and assessed testicular cytokines, apoptosis-related gene expression, and sperm quality. The authors report changes consistent with altered immune signaling and pro-apoptotic pathways, alongside reduced sperm parameters (frequency- and duration-dependent). The conclusion frames these findings as an EMF safety concern and suggests longer daily exposure worsened negative effects.

A Cohort Study on Alzheimer's Disease in Relation to Residential Magnetic Fields From Indoor Transformer Stations

Research RF Safe Research Library Jan 1, 2025

This cohort study evaluated Alzheimer's disease incidence in relation to residential extremely low frequency magnetic fields from indoor transformer stations, using apartment location as an exposure proxy. No significant association was observed between living next to transformer stations and Alzheimer's disease risk (HR 1.02, 95% CI 0.85–1.22). Duration of residence did not materially change risk, and a younger-start subgroup showed a non-significant elevation. The authors note the results did not replicate previously reported positive associations from other residential or occupational studies.

The WHO-commissioned systematic reviews on health effects of radiofrequency radiation provide no assurance of safety

Research RF Safe Research Library Jan 1, 2025

This paper evaluates and critiques 12 WHO-commissioned systematic reviews and meta-analyses on RF-EMF health effects across outcomes including cancer and reproductive endpoints. It argues that serious methodological flaws and limitations in the WHO reviews prevent them from providing assurance of safety for cell phones and other wireless devices. The authors highlight reported evidence in the animal cancer review (high certainty for heart schwannomas; moderate certainty for brain gliomas) and describe dose-related adverse effects on male fertility and reproductive outcomes, including at exposure levels below current ICNIRP thresholds.

Review of the evidence on the influence of Wi-Fi 2.4 GHz radiation on oxidative stress and its possible relationship with Alzheimer's disease

Research RF Safe Research Library Jan 1, 2025

The review states there is no scientific consensus on whether Wi‑Fi (2.4/5 GHz) contributes to Alzheimer's disease through oxidative stress, and that existing results are mixed and inconclusive. It discusses an indirect analysis linking oxidative-stress-responsive genes after 2.4 GHz exposure with genes associated with Alzheimer's disease. The authors suggest chronic exposure could affect regulation of neurodegeneration-related genes (e.g., GSK3B, APOE), while emphasizing that a direct relationship has not been demonstrated and more research is needed.

Microwave and RF Exposure-Induced Molecular and Genetic Alterations

Research RF Safe Research Library Jan 1, 2025

This review discusses recent studies on microwave and RF exposure and their reported impacts on molecular and cytogenetic materials. It states there is growing evidence that RF exposure can induce DNA damage at levels considered safe by current standards, and cites newly reported genetic alterations in rat cancers after lifetime low-level RF exposure. The article concludes that these findings challenge existing exposure guidelines and support reconsideration of regulatory limits.

Causal relationship between the duration of mobile phone use and risk of stroke: A Mendelian randomization study

Research RF Safe Research Library Jan 1, 2025

This Mendelian randomization study assessed whether duration of mobile phone use is causally related to stroke outcomes using GWAS-derived SNP instruments. The inverse-variance weighted analysis reported a significant increased risk for large artery atherosclerosis (LAAS) with longer mobile phone use duration, while other stroke outcomes showed no significant associations. Sensitivity analyses (including MR-Egger and heterogeneity/asymmetry tests) were reported as suggesting the LAAS finding was robust.

Bacterial Adaptation to Radiofrequency Electromagnetic Fields Based on Experiences from Ionizing Radiation

Research RF Safe Research Library Jan 1, 2025

This 2025 review summarizes historical and modern literature on how bacteria may adapt to radiofrequency electromagnetic fields from common sources such as mobile phones and Wi-Fi. It argues that RF-EMF exposure can influence bacterial survival mechanisms and could potentially compromise therapeutic interventions by promoting increased resistance. The authors frame these possibilities as a public health concern and call for continued research and precaution.

Dosimetric Electromagnetic Safety of People With Implants: A Neglected Population?

Research RF Safe Research Library Jan 1, 2025

This dosimetric study evaluated whether existing EM safety guidelines protect individuals with conductive implants by assessing implant-related local field enhancements. Across 10 kHz to 1 GHz, the authors report large increases in psSAR10mg and local electric fields near implants, particularly below 100 MHz. In human anatomical models with implants exposed to an 85 kHz wireless power transfer coil and a 450 MHz dipole, the study reports guideline exceedances and elevated psSAR10mg, while the modeled temperature rise at 450 MHz remained under 0.4 K after six minutes. The authors conclude current guidelines are insufficient for people with implants and propose regulatory changes.

Numerical analysis of the thermal effects on adult with brain pacemaker implantation exposed to WIFI antennas

Research RF Safe Research Library Jan 1, 2025

This numerical study modeled RF exposure from WiFi/5G-type antennas near a 3D brain model with implanted brain pacemakers relevant to Parkinson’s disease. SAR and temperature increases were reported to remain below ICNIRP 2020 limits across modeled conditions, with maxima at a 90° antenna-to-brain angle. Despite compliance with SAR/temperature limits, the authors report modeled thermal strain and tissue displacement that could affect postoperative efficacy, leading them to recommend caution and increased distance from phones.

Bioelectricity in Morphogenesis

Research RF Safe Research Library Jan 1, 2025

This narrative review discusses bioelectricity arising from membrane potentials and its role in morphogenesis beyond neural tissues. It reports that evidence supports bioelectric signals influencing embryonic development, tissue repair, and disease-related processes, and summarizes cellular mechanisms for generating and sensing these signals. The authors also highlight that potential health implications from natural and artificial electromagnetic fields warrant further scientific attention.

Simultaneous 4G and 5G EMF Exposure and Field Uniformity in a Reverberation Chamber for Animal Studies

Research RF Safe Research Library Jan 1, 2025

This engineering study describes the design and validation of a reverberation chamber intended for large-scale animal carcinogenicity research with RF EMF relevant to 4G/5G. E-field uniformity was tested under four loading scenarios, including setups with 80 Sprague-Dawley rats. The chamber achieved better than 1.36 dB E-field uniformity across scenarios, and the authors report a method to predict composite E-field intensity for simultaneous multi-frequency exposures.

The effect of alpha-lipoic acid on liver damage induced by extremely low-frequency electromagnetic fields in a rat model

Research RF Safe Research Library Jan 1, 2025

This rat study assessed whether alpha-lipoic acid (ALA) modifies liver effects from extremely low-frequency magnetic field (ELF-MF) exposure. ELF-MF exposure (2 mT, 4 hours/day for 30 days) was associated with increased liver pathology and higher apoptosis markers (TUNEL, caspase-3) compared with other groups. ALA reduced several histopathological changes and lowered TUNEL/caspase-3, but did not improve fibrosis or biliary proliferation.

Female Crabs Are More Sensitive to Environmentally Relevant Electromagnetic Fields from Submarine Power Cables

Research RF Safe Research Library Jan 1, 2025

This controlled laboratory study examined sex-specific behavioral responses of juvenile shore crabs to magnetic fields intended to represent submarine power cable EMFs. Females showed consistent attraction to EMF-exposed zones across 500–3,200 μT exposures, whereas males showed no consistent spatial preference. The authors suggest such sex-specific sensitivity could disrupt female-driven behaviors relevant to migration and reproduction, with potential ecological implications.

A Systematic Review of the Impact of Electromagnetic Waves on Living Beings

Research RF Safe Research Library Jan 1, 2025

This PRISMA-adherent systematic review searched PubMed, Scopus, and the Cochrane Library for studies (2017–2024) on physiological or behavioral responses to EMF exposure, emphasizing studies reporting harmful or concerning effects. Across 24 included studies (human non-randomized, in vitro, and animal), the review reports negative biological effects including oxidative stress, inflammation, genotoxicity, cardiovascular and fertility-related outcomes, neuronal activity changes, and plant photosynthesis impacts. The authors report that most studies had moderate to high risk of bias and therefore the overall certainty of evidence was lower, and they highlight major gaps in long-term human evidence and exposure standardization.

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