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121 posts

Review of the evidence on the influence of Wi-Fi 2.4 GHz radiation on oxidative stress and its possible relationship with Alzheimer's disease

Research RF Safe Research Library Jan 1, 2025

The review states there is no scientific consensus on whether Wi‑Fi (2.4/5 GHz) contributes to Alzheimer's disease through oxidative stress, and that existing results are mixed and inconclusive. It discusses an indirect analysis linking oxidative-stress-responsive genes after 2.4 GHz exposure with genes associated with Alzheimer's disease. The authors suggest chronic exposure could affect regulation of neurodegeneration-related genes (e.g., GSK3B, APOE), while emphasizing that a direct relationship has not been demonstrated and more research is needed.

Microwave and RF Exposure-Induced Molecular and Genetic Alterations

Research RF Safe Research Library Jan 1, 2025

This review discusses recent studies on microwave and RF exposure and their reported impacts on molecular and cytogenetic materials. It states there is growing evidence that RF exposure can induce DNA damage at levels considered safe by current standards, and cites newly reported genetic alterations in rat cancers after lifetime low-level RF exposure. The article concludes that these findings challenge existing exposure guidelines and support reconsideration of regulatory limits.

Bacterial Adaptation to Radiofrequency Electromagnetic Fields Based on Experiences from Ionizing Radiation

Research RF Safe Research Library Jan 1, 2025

This 2025 review summarizes historical and modern literature on how bacteria may adapt to radiofrequency electromagnetic fields from common sources such as mobile phones and Wi-Fi. It argues that RF-EMF exposure can influence bacterial survival mechanisms and could potentially compromise therapeutic interventions by promoting increased resistance. The authors frame these possibilities as a public health concern and call for continued research and precaution.

Bioelectricity in Morphogenesis

Research RF Safe Research Library Jan 1, 2025

This narrative review discusses bioelectricity arising from membrane potentials and its role in morphogenesis beyond neural tissues. It reports that evidence supports bioelectric signals influencing embryonic development, tissue repair, and disease-related processes, and summarizes cellular mechanisms for generating and sensing these signals. The authors also highlight that potential health implications from natural and artificial electromagnetic fields warrant further scientific attention.

A Systematic Review of the Impact of Electromagnetic Waves on Living Beings

Research RF Safe Research Library Jan 1, 2025

This PRISMA-adherent systematic review searched PubMed, Scopus, and the Cochrane Library for studies (2017–2024) on physiological or behavioral responses to EMF exposure, emphasizing studies reporting harmful or concerning effects. Across 24 included studies (human non-randomized, in vitro, and animal), the review reports negative biological effects including oxidative stress, inflammation, genotoxicity, cardiovascular and fertility-related outcomes, neuronal activity changes, and plant photosynthesis impacts. The authors report that most studies had moderate to high risk of bias and therefore the overall certainty of evidence was lower, and they highlight major gaps in long-term human evidence and exposure standardization.

Effect of electromagnetic radiations from mobile towers on genetic damage and genetic polymorphism in humans: a review on India's perspective

Research RF Safe Research Library Jan 1, 2025

This narrative review examines research on radiofrequency electromagnetic radiation (RF-EMR) from mobile towers and its potential association with genetic damage and genetic polymorphism in humans, with an emphasis on India. The abstract states that RF-EMR exposure may affect genetic material and suggests a link between EMR exposure and genetic damage, with possible implications for cancer risk and cell death. It also highlights that genetic polymorphisms may modify susceptibility and calls for further research to clarify health impacts.

Systematic reviews and meta-analyses for the WHO assessment of health effects of exposure to radiofrequency electromagnetic fields, an introduction

Research RF Safe Research Library Jan 1, 2025

This editorial introduces a special issue supporting the WHO assessment of health effects from RF-EMF exposure, based on nine protocols and twelve systematic reviews developed over four years by more than 80 experts. It summarizes that human evidence for major cancers was moderate-certainty for no or only small effects, with lower certainty for some cancer sites, while animal evidence reported higher-certainty effects for several cancer types and adverse effects on male fertility. For cognition, symptoms, and oxidative stress, certainty was generally lower and findings more variable, and the editors note ongoing methodological challenges and the possibility of unidentified mechanisms.

Carcinogenicity of Radio-Frequency Radiation: Similarities and Differences Between Outcomes of Two Studies

Research RF Safe Research Library Jan 1, 2025

This review compares two epidemiologic studies of radio-frequency radiation (RFR) exposure among military personnel with overlapping patient groups. One study reported a statistically significant increase in cancer among exposed individuals, while the other did not, which the review attributes to a smaller sample size. The review highlights similar cancer patterns across both studies, including a high proportion of hematolymphoid cancers and earlier onset among exposed individuals, and interprets these similarities as evidence of carcinogenic effects.

From particulates to pathways: environmental exposures and their impact on Alzheimer's disease

Research RF Safe Research Library Jan 1, 2025

This review discusses how environmental exposures across air, water, and soil pollutants may influence Alzheimer's disease (AD) onset and progression. It highlights EMFs as a potential aggravating factor, reporting associations with oxidative stress, inflammation, calcium dysregulation, and accelerated amyloid-beta plaque accumulation in animal and human studies. The authors emphasize risk reduction strategies and call for further research and public health interventions.

A scoping review and evidence map of radiofrequency field exposure and genotoxicity: assessing in vivo, in vitro, and epidemiological data

Research RF Safe Research Library Jan 1, 2025

This scoping review and evidence map (PRISMA-ScR) summarizes over 500 studies on RF-EMF exposure and genotoxicity across in vitro, in vivo, and epidemiological research. The authors report a higher proportion of significant DNA damage findings in in vivo and epidemiological studies than in vitro studies, with DNA base damage commonly reported under real-world/pulsed/GSM talk-mode conditions and longer exposures. They conclude that DNA damage has been observed at exposure levels below ICNIRP limits and recommend precautionary measures and updates to guidelines to address potential non-thermal effects.

Impact of Radiofrequency Electromagnetic Fields on Cardiac Activity at Rest: A Systematic Review of Healthy Human Studies

Research RF Safe Research Library Jan 1, 2025

This systematic review evaluated evidence on RF-EMF exposure and cardiac activity (heart rate and heart rate variability) in healthy humans at rest. Across 28 studies spanning 100 to 110,000 MHz and exposures from minutes to a week, most studies reported no significant effects on resting heart rate, and HRV findings were largely null under calm conditions. Some position-dependent HRV changes were reported, and the authors note possible effects during physiological challenges, but conclude evidence is insufficient for firm conclusions beyond resting healthy populations.

Comparative Analysis of Beamforming Techniques and Beam Management in 5G Communication Systems

Research RF Safe Research Library Jan 1, 2025

This engineering paper reviews and classifies beamforming techniques in 5G New Radio and examines beam management procedures at Layer 1 and Layer 2. It analyzes the spectral spectrogram of Synchronization Signal Blocks (SSBs) to illustrate how configuration parameters influence spectral occupancy and synchronization-related performance in different deployment scenarios, including FR2. The work is framed as technical optimization, with only a general note that such knowledge may inform safety considerations related to EMF exposure.

Weak Radiofrequency Field Effects on Biological Systems Mediated through the Radical Pair Mechanism

Research RF Safe Research Library Jan 1, 2025

This 2025 review examines claims of biological effects from weak, nonthermal RF magnetic fields and evaluates whether such effects could be mediated by the radical pair mechanism (RPM). It reports that aligning RPM theory with low-level experimental observations remains difficult and that many experimental findings are limited by reproducibility, statistical robustness, and dosimetry issues. The authors conclude a tangible but incompletely understood link may exist and emphasize the need for more rigorous, standardized, interdisciplinary work.

Low frequency magnetic field exposure and neurodegenerative disease: systematic review of animal studies

Research RF Safe Research Library Jan 1, 2025

This systematic review synthesizes animal studies on low frequency magnetic field exposure in relation to neurodegenerative diseases. It reports no support for a causal induction of Alzheimer’s-type neuropathology in naive animals, while noting that evidence is too limited to draw strong conclusions for motor neuron disease, multiple sclerosis, and Parkinson’s disease regarding induced neuropathology. In models with pre-existing neurodegenerative disease, the review describes possible therapeutic effects on behavioral and neuroanatomical outcomes for dementia-related conditions, and no apparent effect on motor neuron disease progression.

Exposure to radiofrequency electromagnetic fields and IARC carcinogen assessment: Risk of Bias preliminary literature assessment for 10 key characteristics of human carcinogens

Research RF Safe Research Library Jan 1, 2025

This review examined experimental literature on whether RF-EMF exposures within ICNIRP (2020) limits affect IARC key characteristics of human carcinogens. It identified 159 articles and found that 38% of in vitro/in vivo measurements reported statistically significant effects, but higher study quality was associated with fewer reported effects and there was no consistent exposure-response pattern. The authors state that study diversity and generally poor quality prevent high-confidence conclusions for most key characteristics, while recommending replication of the few higher-quality positive findings under stringent standards.

Electromagnetic fields from mobile phones: A risk for maintaining energy homeostasis?

Research RF Safe Research Library Jan 1, 2025

This narrative review discusses low-intensity RF-EMF exposure, primarily from mobile phones, with a focus on thermoregulation and energy homeostasis. It reports that many rodent studies at 900 MHz describe cold-like thermoregulatory and behavioral responses and molecular findings suggestive of WAT browning, while BAT transcriptional changes typical of cold exposure were not observed. The authors indicate short-term adaptations may not disrupt homeostasis, but emphasize uncertainty about long-term consequences and call for further research, including at 5G-relevant frequencies.

Effects of Polarized Coherent Microwaves Modulated at Extremely Low Frequencies

Research RF Safe Research Library Jan 1, 2025

This review-style text discusses polarized, coherent microwaves that are modulated and pulsed at extremely low frequencies (ELF) and suggests these characteristics may increase biological interactions. It emphasizes that intensity variability and ELF modulation are important for understanding EMF–biology interactions. It also states that such exposures have been linked to health risks in the scientific literature, framing the topic as relevant to EMF safety and public health risk mitigation.

A comprehensive mechanism of biological and health effects of anthropogenic extremely low frequency and wireless communication electromagnetic fields

Research RF Safe Research Library Jan 1, 2025

This narrative review discusses biological mechanisms and reported health effects of anthropogenic extremely low frequency (ELF) and wireless communication (WC) electromagnetic fields. It highlights oxidative stress and DNA damage as key mechanistic endpoints and proposes an IFO-VGIC pathway linking EMF exposure to ROS overproduction and cellular dysfunction. The authors interpret the broader literature as indicating risks (e.g., cancer, infertility, EHS) even below current exposure limits and advocate precautionary policy measures, including stricter limits and a 5G moratorium.

Rapid Deployment of 5G Wireless Communication and Risk Assessment on Human Health: Quid Novi?

Research RF Safe Research Library Jan 1, 2025

This review discusses the rapid deployment of 5G and the associated debate about potential human health impacts from EMF exposure, particularly at 3.5–26 GHz including millimeter waves. It emphasizes limited published studies in these exposure ranges and highlights EU-funded initiatives and research consortia aimed at closing knowledge gaps. The authors state that guidelines are generally considered adequate at present, but argue that uncertainties—especially regarding long-term exposure—support continued research and precautionary approaches.

Epidemiological criteria for causation applied to human health harms from RF-EMF exposure: Bradford Hill revisited

Research RF Safe Research Library Jan 1, 2025

This paper is a commentary reviewing how Bradford Hill’s epidemiological criteria can be applied to multidisciplinary evidence on RF-EMF exposure and adverse health effects. It reports that systematic reviews and meta-analyses in this area often reach substantially different conclusions, and argues that key weaknesses in primary studies—especially exposure measurement error and insufficient time for long-latency tumors—help explain the divergence. The author suggests these limitations may cause underestimation of potential causation if the associations are truly causal, and calls for independent guidelines to improve future epidemiological research quality.

Exploring the impact of environmental factors on male reproductive health through epigenetics

Research RF Safe Research Library Jan 1, 2025

This narrative review discusses how environmental factors may affect male reproductive health through epigenetic mechanisms, including DNA methylation, histone modifications, chromatin remodeling, and non-coding RNA regulation. It reports that electromagnetic radiation, particularly from mobile phones and wireless devices, is linked in the reviewed literature to reduced sperm count and motility, increased oxidative stress, and chromatin damage. The authors conclude there is a substantive connection between EMF exposure and adverse male reproductive outcomes and suggest practical risk-reduction guidance.

Potential Impacts of Radiofrequency Electromagnetic Fields on the Central Nervous System, Brain Neurotransmitter Dynamics and Reproductive System

Research RF Safe Research Library Jan 1, 2025

This review discusses potential impacts of radiofrequency electromagnetic fields from technologies such as Wi‑Fi and mobile phones on the central nervous system, neurotransmitter dynamics, and reproductive health. It describes proposed mechanisms including oxidative stress, thermal effects, altered neurotransmitter activity, ion channel changes, and neuronal apoptosis, while acknowledging conflicting evidence. The authors note that Wi‑Fi RF exposure has not been confirmed to exceed safety guidelines but argue that updated standards and long-term studies are needed, particularly for children/adolescents and in the context of expanding technologies such as 5G.

Electromagnetic fields regulate iron metabolism: From mechanisms to applications

Research RF Safe Research Library Jan 1, 2025

This review synthesizes evidence that electromagnetic field (EMF) exposure is associated in the literature with changes in systemic and cellular iron metabolism, with reported effects varying by EMF parameters, exposure duration, and biological context. It proposes mechanistic pathways involving iron-containing proteins/tissues, membrane and ion channel modulation, and reactive oxygen species (ROS). The authors frame iron-metabolism modulation as relevant to both therapeutic applications and safety evaluation, while emphasizing inconsistencies and the need for standardized exposure protocols.

A Mini-Review of the Potential Health Impacts of Indoor Radiation Exposure in Companion Animals

Research RF Safe Research Library Jan 1, 2025

This mini-review discusses indoor radiation sources that may affect companion animals, including radon, radionuclides in feed, radiofrequency sources (phones, Wi-Fi, pet tracking devices), solar radiation, and extremely low frequency radiation. It reports that indoor radiation may negatively impact companion animal health and well-being. The authors conclude that preventive and precautionary measures are necessary to protect companion animals from indoor radiation exposure.

Exploring the influence of Schumann resonance and electromagnetic fields on bioelectricity and human health

Research RF Safe Research Library Jan 1, 2025

This review examines links between extremely low-frequency electromagnetic fields, especially the Schumann resonance at ~7.83 Hz, and biological regulation of bioelectricity. It describes proposed mechanisms involving calcium flux modulation and downstream effects on neural activity (including EEG) and circadian rhythms. The article presents both potential benefits from controlled ELF exposures (e.g., therapeutic applications) and potential harms from artificial EMFs disrupting key physiological processes, while emphasizing the need for further research.

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