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Showing results for: mechanisms

Effects of Extremely Low-Frequency Electromagnetic Field Treatment on ASD Symptoms in Children: A Pilot Study.

Research RF Safe Research Library Jan 1, 2024

This pilot study treated 20 children with ASD (ages 2–13) with a 15-week extremely low-frequency electromagnetic field (ELF-EMF) protocol using the SEQEX device. The abstract reports statistically significant improvements in receptive and expressive language and reductions in externalizing/behavioral problems, with…

The extremely low-frequency electromagnetic field (50 Hz) can establish a new "set-point" for the activity of the locus coeruleus-noradrenergic (LC-NA) system in rat.

Research RF Safe Research Library Jan 1, 2024

This animal study exposed rats to 50 Hz ELF-EMF at 1 mT or 7 mT for 1 hour/day over 7 days, repeated across three cycles, and assessed catecholamines, MHPG, β2-adrenergic receptor expression, and behavior. The authors report that ELF-EMF influences stress-response mechanisms involving the locus…

It is the Frequency that Matters: Effects of Electromagnetic Fields on the Release and Content of Extracellular Vesicles.

Research RF Safe Research Library Jan 1, 2023

This preprint describes an in vitro bioreactor-based system to test whether electromagnetic/electrical stimulation affects extracellular vesicles (EVs). Using proteomics and single-vesicle flow cytometry, the authors report that stimulation at physiological current amplitudes can modulate EV content in a…

Cellular Mechanisms of Electromagnetic Field in Traumatic Brain Injury.

Research RF Safe Research Library Jan 1, 2023

This paper reviews literature from 1980–2023 on the role of electromagnetic fields as a therapy for traumatic brain injury and brain neuropathology. It reports that existing findings suggest electromagnetic therapy may be a promising non-invasive treatment approach. The authors emphasize that current evidence is…

Electromagnetic Fields Literature Analysis for Precision Medicine.

Research RF Safe Research Library Jan 1, 2023

This paper describes a literature-mining analysis of more than 30,000 EMF-related publications to extract genes, diseases, and molecular mechanisms linked to EMF exposure across six EMF subsets. The authors report identifying 3,653 unique disease MeSH terms and 9,966 unique genes, including 4,340 human genes. The…

Low-energy amplitude-modulated radiofrequency electromagnetic fields as a systemic treatment for cancer: Review and proposed mechanisms of action

Research RF Safe Research Library Sep 8, 2022

This review discusses low-energy amplitude-modulated RF EMF (27.12 MHz carrier with low Hz–kHz envelope modulation) delivered systemically via intrabuccal antenna devices as a potential treatment for advanced hepatocellular carcinoma. It reports preclinical inhibition of cancer growth in vitro and in mouse xenograft…

Exposure to long-term evolution radiofrequency electromagnetic fields decreases neuroblastoma cell proliferation via Akt/mTOR-mediated cellular senescence.

Research RF Safe Research Library Jan 1, 2021

This in vitro study examined LTE RF-EMF exposure effects on SH-SY5Y neuroblastoma cells. The authors report reduced cell proliferation and a G0/G1 cell-cycle delay after 1760 MHz exposure at 4 W/kg for 4 hr/day over 4 days. They report no marked DNA damage signal (γH2AX) and no apoptosis activation, but increased…

Electromagnetic field treatment increases purinergic receptor P2X7 expression and activates its downstream Akt/GSK3β/β-catenin axis in mesenchymal stem cells under osteogenic induction.

Research RF Safe Research Library Jan 1, 2019

This study examined how electromagnetic field (EMF) treatment influences osteogenic differentiation mechanisms in human bone marrow mesenchymal stem cells and tested a combined therapy in an ovariectomized rat osteoporosis model. The authors report that EMF exposure increased P2X7 receptor expression during…

Emerging medical applications based on non-ionizing electromagnetic fields from 0 Hz to 10 THz.

Research RF Safe Research Library Jan 1, 2019

This review discusses medical applications of non-ionizing electromagnetic fields spanning 0 Hz to the THz range, focusing mainly on therapeutic uses and mentioning few diagnostic approaches. It reports that current EMF-based methods generally have limited clinical impact and are not expected to replace conventional…

Experimental research on the electromagnetic radiation (EMR) characteristics of cracked rock.

Research RF Safe Research Library Jan 1, 2018

This experimental study examined electromagnetic radiation (EMR) emitted by coal rock with prefabricated cracks during mechanical loading. The authors report that intact rock EMR increased with loading, whereas cracked rock EMR showed staged and fluctuating behavior that became more pronounced as crack angle…

Theta-gamma coupling in hippocampus during working memory deficits induced by low frequency electromagnetic field exposure.

Research RF Safe Research Library Jan 1, 2017

This mouse study examined whether 50 Hz, 1 mT electromagnetic field exposure affects working memory and hippocampal electrophysiology. The authors report reduced Y-maze working memory performance after 3 days of EMF exposure, accompanied by decreased hippocampal firing rates. They also report reduced theta and…

Cytotoxicity of temozolomide on human glioblastoma cells is enhanced by the concomitant exposure to an extremely low-frequency electromagnetic field (100Hz, 100G).

Research RF Safe Research Library Jan 1, 2017

This in vitro study tested whether an extremely low-frequency EMF (100 Hz, 100 G) could enhance temozolomide cytotoxicity in human glioma cell lines (U87 and T98G). The authors report that combined EMF and temozolomide increased apoptosis relative to either treatment alone and was accompanied by changes in…

Radiation from wireless technology elevates blood glucose and body temperature in 40-year-old type 1 diabetic male.

Research RF Safe Research Library Jan 1, 2017

This case report describes a 40-year-old male with type 1 diabetes who reported repeated episodes of markedly elevated blood glucose associated with nearby microwave radiation from wireless technology, with decreases after exposure ended. In one episode, body temperature also increased, and both measures reportedly…

Epitaxy of the bound water phase on hydrophilic surfaces of biopolymers as key mechanism of microwave radiation effects on living objects.

Research RF Safe Research Library Jan 1, 2017

This study examined proposed mechanisms of microwave radiation effects using a bacterial culture and a sterile growth medium, focusing on a sensor bioluminescence system. The authors report irradiation-related changes in UV spectral properties (200–350 nm), luminescence, NMR relaxation parameters, bacterial growth,…

[Genic and non-genic regulation of low frequence pulsed electromagnetic fields on osteoblasts differentiation].

Research RF Safe Research Library Jan 1, 2016

This in vitro study exposed rat calvarial osteoblasts to 50 Hz, 0.6 mT pulsed electromagnetic fields for 1.5 hours and measured early differentiation-related markers over 0–12 hours. The abstract reports increased ALP activity at 3 hours and time-dependent changes in ALP, Runx2, and OSX transcription and Runx2/OSX…

Effect of exposure to extremely low frequency magnetic fields on melatonin levels in calves is seasonally dependent

Research RF Safe Research Library Sep 18, 2015

This animal study measured salivary melatonin in 1–2 month old calves exposed to 50 Hz extremely low frequency magnetic fields in the hundreds of nT range. The authors report a season-dependent response: melatonin decreased with exposure in winter but increased in summer. They suggest future studies should consider…

Effects of microwave radiation on brain energy metabolism and related mechanisms

Research RF Safe Research Library Feb 17, 2015

This paper is a narrative review of microwave radiation and brain energy metabolism. The abstract frames the brain as a sensitive target organ and highlights mitochondrial injury and energy metabolism disorders as important in microwave radiation-induced brain damage. It aims to summarize biological effects, brain…

[Modulation of Ca(2+)-Dependent Proteiolysis under the Action of Weak Low-Frequency Magnetic Fields].

Research RF Safe Research Library Jan 1, 2015

This animal/model-organism study examined whether weak low-frequency magnetic fields tuned to a proposed parametric resonance for calcium ions affect Ca(2+)-dependent proteolysis. It reports time-dependent modulation of Ca(2+)-dependent proteinase activity in fish and whelk and states that a minimal exposure time for…

2.45-GHz microwave irradiation adversely affects reproductive function in male mouse, Mus musculus by inducing oxidative and nitrosative stress

Research RF Safe Research Library Jan 1, 2014

This animal study exposed 12-week-old male Swiss strain mice to non-thermal low-level 2.45-GHz microwave radiation for 2 hours per day over 30 days (SAR 0.018 W/kg). The abstract reports reduced sperm count and viability, testicular structural changes, lower 3β-HSD activity and plasma testosterone, and increased…

Melatonin protects rat cerebellar granule cells against electromagnetic field-induced increases in Na(+) currents through intracellular Ca(2+) release

Research RF Safe Research Library Jan 1, 2014

This in vitro study examined extremely low-frequency electromagnetic field (ELF-EMF) effects on voltage-gated sodium (Nav) currents in rat cerebellar granule cells and whether melatonin modifies these effects. The abstract reports that 60 minutes of ELF-EMF exposure increased Nav current density, and that melatonin…

[Mechanism of action of combined extremely weak magnetic field on aqueous solution of amino acid].

Research RF Safe Research Library Jan 1, 2014

The paper reviews and analyzes mechanisms for resonance action of extremely weak alternating magnetic fields (40 nT) combined with weak static fields (40 μT), tuned to cyclotron frequencies. It references prior reports of narrow resonant peaks in electrical conductivity of aqueous solutions and biomedical effects in…

EMOST: elimination of chronic constipation and diarrhea by low-frequency and intensity electromagnetic fields.

Research RF Safe Research Library Jan 1, 2014

This paper reports routine EMOST (Electro-Magnetic-Own-Signal-Treatment) use with low-frequency, low-intensity electromagnetic fields in two children with chronic constipation and persistent diarrhea. The authors state these conditions were eliminated following treatment. The abstract briefly discusses possible…

Specific absorption rate variation in a brain phantom due to exposure by a 3G mobile phone: problems in dosimetry.

Research RF Safe Research Library Jan 1, 2013

This paper describes a SAR measurement system for a 3G mobile phone (1718.5 MHz) using brain phantom material in a Perspex box sized to a small rat volume, with induced fields measured at multiple locations. SAR was computed from induced-field measurements and also estimated experimentally via temperature rise, with…

Hyperthermic effects of dissipative structures of magnetic nanoparticles in large alternating magnetic fields.

Research RF Safe Research Library Jan 1, 2011

This paper addresses heat dissipation mechanisms of magnetic nanoparticles used in targeted hyperthermia under large alternating magnetic fields. Using numerical comparisons, it reports additional features in relaxation loss for rotatable superparamagnetic nanoparticles and field-induced formation of oriented…

Anomalous magnetic field dependence of Y Ba(2)Cu(3)O(7 - δ): effect of orthorhombic distortion.

Research RF Safe Research Library Jan 1, 2010

This paper presents a theoretical model to investigate the origin of a mixed symmetry pairing state in the high-Tc superconductor YBa2Cu3O7-δ under applied magnetic fields between Hc1 and Hc2. The authors report that the model’s results, and their stated agreement with relevant experimental data, suggest orthorhombic…

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