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Radiofrequency Electromagnetic Field Emissions and Neurodevelopmental Outcomes in Infants: A Prospective Cohort Study

Research RF Safe Research Library Jan 1, 2025

This prospective cohort study followed 105 neonates/infants for one year and measured household RF-EMF using a selective radiation meter, categorizing exposure into tertiles. Higher household RF-EMF exposure was associated with lower ASQ-3 neurodevelopmental scores, particularly in motor and problem-solving domains, and higher odds of monitor/refer classifications for fine motor and problem-solving. The abstract notes these associations persisted after adjustment for low birth weight, though exposure was measured at a single time point and key confounders (e.g., prenatal phone use, parental interaction) were not assessed.

Impact of Radiofrequency Electromagnetic Fields on Cardiac Activity at Rest: A Systematic Review of Healthy Human Studies

Research RF Safe Research Library Jan 1, 2025

This systematic review evaluated evidence on RF-EMF exposure and cardiac activity (heart rate and heart rate variability) in healthy humans at rest. Across 28 studies spanning 100 to 110,000 MHz and exposures from minutes to a week, most studies reported no significant effects on resting heart rate, and HRV findings were largely null under calm conditions. Some position-dependent HRV changes were reported, and the authors note possible effects during physiological challenges, but conclude evidence is insufficient for firm conclusions beyond resting healthy populations.

Smartphone Usage Patterns and Sleep Behavior in Demographic Groups: Retrospective Observational Study

Research RF Safe Research Library Jan 1, 2025

This retrospective observational study analyzed Murmuras app data from 1074 participants in 2022 to examine demographic differences in smartphone use and nocturnal smartphone inactivity duration (a proxy for sleep-related behavior). Nighttime smartphone use increased, especially for social media and entertainment, and usage patterns varied by gender, age, education, and employment status. Most demographic groups showed no significant correlation between usage duration and nocturnal inactivity, although some subgroups showed correlations in either direction. The authors frame excessive nighttime smartphone use as potentially adverse for sleep and link this behavioral exposure to electromagnetic fields with sleep health risks.

Single-cell analysis reveals the spatiotemporal effects of long-term electromagnetic field exposure on the liver

Research RF Safe Research Library Jan 1, 2025

This animal study exposed mice to 2.45 GHz electromagnetic fields daily for up to 5 months and assessed liver effects using serum tests, lipidomics, histology, and single-cell/spatiotemporal transcriptomics. The authors report that hepatic cell types differed in sensitivity, with hepatocytes, endothelial cells, and monocytes showing notable transcriptomic disruptions. Reported changes involved lipid metabolism and immune regulation and were spatially enriched in peri-portal liver regions. The authors frame the findings as evidence of significant biological impacts on the liver from long-term EMF exposure.

Microleakage of Amalgam Restorations after Exposure to Electromagnetic Fields of a Commercial Hair Dryer: An Ex-Vivo Study

Research RF Safe Research Library Jan 1, 2025

This ex-vivo experimental study tested whether electromagnetic fields from a commercial hair dryer affect microleakage of class V dental amalgam restorations in 100 extracted human teeth. Several exposure groups showed significantly higher dye-penetration microleakage scores than the unexposed control, while one exposure condition did not differ from control. The authors conclude that hair-dryer EMF exposure can increase microleakage and potentially compromise restoration integrity.

Radiofrequency electromagnetic fields reduce bumble bee visitation to flowers

Research RF Safe Research Library Jan 1, 2025

This blinded, two-year study examined whether RF-EMF exposure at 2.4 and 5.8 GHz affects pollinator visitation to Salvia and Lavandula. The authors report no significant effect on honey bee visitation rates. They report a significant reduction in bumble bee visits per observation period under RF-EMF exposure, which they frame as a potential risk warranting further long-term research.

Exposure to radiofrequency electromagnetic fields and IARC carcinogen assessment: Risk of Bias preliminary literature assessment for 10 key characteristics of human carcinogens

Research RF Safe Research Library Jan 1, 2025

This review examined experimental literature on whether RF-EMF exposures within ICNIRP (2020) limits affect IARC key characteristics of human carcinogens. It identified 159 articles and found that 38% of in vitro/in vivo measurements reported statistically significant effects, but higher study quality was associated with fewer reported effects and there was no consistent exposure-response pattern. The authors state that study diversity and generally poor quality prevent high-confidence conclusions for most key characteristics, while recommending replication of the few higher-quality positive findings under stringent standards.

A novel approach for assessments of radiofrequency electromagnetic fields exposure in buildings near telecommunication infrastructure

Research RF Safe Research Library Jan 1, 2025

This paper proposes a new methodology to better assess indoor RF-EMF exposure in buildings near telecommunication base station antennas by refining measurement-point selection. Implemented in four multi-storey buildings in Natal, Brazil, indoor electric field peaks and averages were reported to be substantially higher than ground-level measurements. Although the highest indoor levels remained below ICNIRP recommended limits, the authors argue current regulatory evaluation methods may underestimate indoor exposure in certain building locations.

Auto-Induced Downlink Radiofrequency Electromagnetic Field Exposure at 3.5 GHz With Focusing Near the Head

Research RF Safe Research Library Jan 1, 2025

This exposure-assessment study uses FDTD simulations to evaluate auto-induced downlink RF-EMF exposure at 3.5 GHz when downlink energy is focused toward user equipment near the head. Exposure varied substantially by device position (ear, eyes, nose) and by the precoding technique used. The authors report that the choice of normalization strategy can produce cases where ICNIRP basic restrictions are exceeded even when reference levels appear compliant, motivating a precautionary framing for compliance assessment.

In-Situ Measurements of Radiofrequency Electromagnetic Fields Measurements Around 5G Macro Base Stations in the UK

Research RF Safe Research Library Jan 1, 2025

This exposure assessment performed RF spot measurements in line-of-sight to 56 active 5G macro base stations across 30 publicly accessible UK locations. Power density was measured across 420 MHz–6 GHz under multiple scenarios (background, streaming, downlink speed test, and extrapolated SS-RSRP decoding). Reported total RF and 5G-specific levels were within 1998 ICNIRP public reference levels, with 4G downlink contributing most of the measured exposure.

Histomorphometric study of thyroid tissue in juvenile rats exposed to 5G electromagnetic fields

Research RF Safe Research Library Jan 1, 2025

This animal study examined thyroid histomorphometry in juvenile male Wistar rats after 2 weeks of 5G EMF exposure (3.5 GHz, 1.5 V/m). Exposed rats showed larger follicle and colloid areas and a significantly lower Thyroid Activation Index, which the authors interpret as thyroid hypoactivity. The authors suggest this may represent a potential health risk and call for further work including hormone assays and mechanistic studies.

Electromagnetic fields from mobile phones: A risk for maintaining energy homeostasis?

Research RF Safe Research Library Jan 1, 2025

This narrative review discusses low-intensity RF-EMF exposure, primarily from mobile phones, with a focus on thermoregulation and energy homeostasis. It reports that many rodent studies at 900 MHz describe cold-like thermoregulatory and behavioral responses and molecular findings suggestive of WAT browning, while BAT transcriptional changes typical of cold exposure were not observed. The authors indicate short-term adaptations may not disrupt homeostasis, but emphasize uncertainty about long-term consequences and call for further research, including at 5G-relevant frequencies.

Characterization of the Core Temperature Response of Free-Moving Rats to 1.95 GHz Electromagnetic Fields

Research RF Safe Research Library Jan 1, 2025

This animal study measured core body temperature in free-moving male and female Sprague Dawley rats during and after 3-hour exposure to 1.95 GHz RF-EMF at multiple whole-body average SAR levels. A measurable thermal response was reported at 4 W/kg, while lower SAR conditions showed smaller or no significant temperature increases. The authors note that temperature dropped quickly after exposure ended, implying post-exposure measurements may underestimate peak heating.

The Influence of an Electromagnetic Field at a Radiofrequency of 900 MHz on the Behavior of a Honey Bee

Research RF Safe Research Library Jan 1, 2025

This laboratory study examined whether a 900 MHz radiofrequency electromagnetic field (RF-EMF) influences the behavior of newly emerged honey bee workers. Compared with controls, the exposed groups showed behavioral changes, with some parameters showing statistically significant differences seven days after exposure. The authors frame RF-EMF as a potential environmental stressor and call for further research, including gene expression analyses.

Mitigation of 3.5 GHz Electromagnetic Field-Induced BV2 Microglial Cytotoxicity by Polydeoxyribonucleotide

Research RF Safe Research Library Jan 1, 2025

This in vitro study exposed BV2 mouse microglial cells to 3.5 GHz EMF for 2 hours and reports reduced cell growth and increased apoptosis alongside oxidative stress and signaling changes. The authors report that ROS generation and activation of JNK-1/2 and p38 MAPK were key events in the observed cytotoxicity. Polydeoxyribonucleotide (PDRN) reportedly reduced several EMF-associated cytotoxicity markers, suggesting a potential mitigating effect under the tested conditions.

A comprehensive mechanism of biological and health effects of anthropogenic extremely low frequency and wireless communication electromagnetic fields

Research RF Safe Research Library Jan 1, 2025

This narrative review discusses biological mechanisms and reported health effects of anthropogenic extremely low frequency (ELF) and wireless communication (WC) electromagnetic fields. It highlights oxidative stress and DNA damage as key mechanistic endpoints and proposes an IFO-VGIC pathway linking EMF exposure to ROS overproduction and cellular dysfunction. The authors interpret the broader literature as indicating risks (e.g., cancer, infertility, EHS) even below current exposure limits and advocate precautionary policy measures, including stricter limits and a 5G moratorium.

5G-exposed human skin cells do not respond with altered gene expression and methylation profiles

Research RF Safe Research Library Jan 1, 2025

This in vitro study exposed human skin cells (fibroblasts and keratinocytes) to 5G-band electromagnetic fields for 2 hours and 48 hours using a fully blinded design. Exposures were up to ten times permissible limits, with sham exposure as a negative control and UV exposure as a positive control. The study reports that observed gene expression and DNA methylation differences were minor and consistent with random variation, supporting no detectable EMF-related effect under the tested conditions.

Exposure Perception and Symptom Reporting in Idiopathic Environmental Intolerance Attributed to Electromagnetic Fields Using a Co-Designed Provocation Test

Research RF Safe Research Library Jan 1, 2025

This co-designed provocation study in IEI-EMF volunteers evaluated whether perceived exposure and symptom reporting tracked actual EMF exposure under double-blind conditions. The abstract reports no consistent alignment between perceived exposure certainty or symptoms and true exposure status at the group level, with limited individual exceptions. Symptom reporting was related to certainty of being exposed for about half of participants, which the authors interpret as supporting a nocebo-type mechanism and motivating refinement of provocation protocols.

What is the effect of alarmist media and radiofrequency electromagnetic field (RF-EMF) exposure on salivary cortisol and non-specific symptoms?

Research RF Safe Research Library Jan 1, 2025

This randomized study tested whether viewing alarmist media and participating in an open-label RF-EMF provocation trial influenced non-specific symptoms and salivary cortisol. Participants who believed they were being exposed reported more symptoms than those who believed they were not exposed. The study did not find a replicated effect of alarmist media or open-label RF-EMF exposure on salivary cortisol, suggesting reported symptoms were more related to perception than cortisol-measured stress.

Potential Impacts of Radiofrequency Electromagnetic Fields on the Central Nervous System, Brain Neurotransmitter Dynamics and Reproductive System

Research RF Safe Research Library Jan 1, 2025

This review discusses potential impacts of radiofrequency electromagnetic fields from technologies such as Wi‑Fi and mobile phones on the central nervous system, neurotransmitter dynamics, and reproductive health. It describes proposed mechanisms including oxidative stress, thermal effects, altered neurotransmitter activity, ion channel changes, and neuronal apoptosis, while acknowledging conflicting evidence. The authors note that Wi‑Fi RF exposure has not been confirmed to exceed safety guidelines but argue that updated standards and long-term studies are needed, particularly for children/adolescents and in the context of expanding technologies such as 5G.

Electromagnetic fields regulate iron metabolism: From mechanisms to applications

Research RF Safe Research Library Jan 1, 2025

This review synthesizes evidence that electromagnetic field (EMF) exposure is associated in the literature with changes in systemic and cellular iron metabolism, with reported effects varying by EMF parameters, exposure duration, and biological context. It proposes mechanistic pathways involving iron-containing proteins/tissues, membrane and ion channel modulation, and reactive oxygen species (ROS). The authors frame iron-metabolism modulation as relevant to both therapeutic applications and safety evaluation, while emphasizing inconsistencies and the need for standardized exposure protocols.

Active matter as the underpinning agency for extraordinary sensitivity of biological membranes to electric fields

Research RF Safe Research Library Jan 1, 2025

This biophysics paper presents a nonequilibrium (active matter) statistical mechanics model for electromechanical biological membranes. It argues that energy-driven activity in membranes could enable detection of electric fields far below equilibrium thermal-noise limits, and reports that the model can reproduce experimental observations by tuning activity. The abstract frames this as a potential mechanistic link between weak electromagnetic fields and biological responses, while also noting future modeling directions and possible implications for exposure safety discussions.

An 1800 MHz Electromagnetic Field Affects Hormone Levels, Sperm Quality, and Behavior in Laboratory Rats

Research RF Safe Research Library Jan 1, 2025

This animal study exposed rats to a 1800 MHz electromagnetic field for 12 weeks and assessed hormones, sperm quality, and behavior. The abstract reports increased corticosterone, decreased thyroid-stimulating hormone, reduced sperm motility/viability, and increased anxiety-like behavior in exposed rats. Some hormonal changes reportedly persisted for at least 2 weeks after exposure ended, and the authors frame the results as indicating adverse endocrine, reproductive, and behavioral effects.

Exploring the influence of Schumann resonance and electromagnetic fields on bioelectricity and human health

Research RF Safe Research Library Jan 1, 2025

This review examines links between extremely low-frequency electromagnetic fields, especially the Schumann resonance at ~7.83 Hz, and biological regulation of bioelectricity. It describes proposed mechanisms involving calcium flux modulation and downstream effects on neural activity (including EEG) and circadian rhythms. The article presents both potential benefits from controlled ELF exposures (e.g., therapeutic applications) and potential harms from artificial EMFs disrupting key physiological processes, while emphasizing the need for further research.

Effect of Occupational Exposure to Low-frequency Electromagnetic Fields on Cataract Development

Research RF Safe Research Library Jan 1, 2025

This cross-sectional epidemiologic study enrolled 100 employees of an electricity company to assess whether occupational low-frequency electromagnetic field exposure is associated with cataract development. Cataract frequency was higher in exposed versus non-exposed groups, and nuclear opacity grading differed significantly between groups. Within exposed workers, nuclear and posterior subcapsular cataract grades were associated with longer work experience, suggesting occupational exposure may be a risk factor, particularly for nuclear cataracts.

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