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Cellular Mechanisms of Electromagnetic Field in Traumatic Brain Injury.

Research RF Safe Research Library Jan 1, 2023

This paper reviews literature from 1980–2023 on the role of electromagnetic fields as a therapy for traumatic brain injury and brain neuropathology. It reports that existing findings suggest electromagnetic therapy may be a promising non-invasive treatment approach. The authors emphasize that current evidence is…

EMAGINE-Study protocol of a randomized controlled trial for determining the efficacy of a frequency tuned electromagnetic field treatment in facilitating recovery within the subacute phase following ischemic stroke.

Research RF Safe Research Library Jan 1, 2023

This paper presents the protocol for the EMAGINE multicenter, double-blind, randomized, sham-controlled trial testing an extremely low-frequency, low-intensity, frequency-tuned electromagnetic field therapy (ENTF) after subacute ischemic stroke. Participants will start active or sham treatment 4–21 days post-stroke,…

50 Hz Magnetic Field Exposure Inhibited Spontaneous Movement of Zebrafish Larvae through ROS-Mediated syn2a Expression.

Research RF Safe Research Library Jan 1, 2023

This zebrafish study exposed embryos to a 50 Hz magnetic field at 100–800 μT for 1 h or 24 h daily over 5 days. The authors report no changes in hatching, mortality, or malformation rates, but report reduced spontaneous movement at 200 μT along with brain histological abnormalities. They also report increased ROS and…

Impact of ketamine administration on chronic unpredictable stress-induced rat model of depression during extremely low-frequency electromagnetic field exposure: Behavioral, histological and molecular study.

Research RF Safe Research Library Jan 1, 2023

This animal study evaluated ketamine administration combined with extremely low-frequency electromagnetic field (ELF-EMF) exposure in a chronic unpredictable stress (CUS) rat model. The authors report that the combined treatment increased depression-like behavior and neuronal degeneration, reduced GFAP(+) cells in…

Numerical Modeling and Computer Simulation of a Meander Line Antenna for Alzheimer's Disease Treatment, a Feasibility Study.

Research RF Safe Research Library Jan 1, 2023

This feasibility study reports numerical modeling and HFSS simulations of a portable meander line antenna intended to deliver repeated electromagnetic field stimulation at 64 MHz for potential Alzheimer's disease treatment. Using two numerical head phantoms, the authors simulated E/H fields and SAR with a 50-W input…

Immunomodulatory Effect of Electromagnetic Field in the Treatment of Traumatic Brain Injury.

Research RF Safe Research Library Jan 1, 2023

This paper reports a PubMed and Google Scholar-based review of EMF research related to brain pathology, with emphasis on ischemic and traumatic brain injury. It provides a critical overview of the state of the art and describes the authors’ experimental and ongoing studies. The authors conclude that EMF applications…

Low-energy amplitude-modulated radiofrequency electromagnetic fields as a systemic treatment for cancer: Review and proposed mechanisms of action

Research RF Safe Research Library Sep 8, 2022

This review discusses low-energy amplitude-modulated RF EMF (27.12 MHz carrier with low Hz–kHz envelope modulation) delivered systemically via intrabuccal antenna devices as a potential treatment for advanced hepatocellular carcinoma. It reports preclinical inhibition of cancer growth in vitro and in mouse xenograft…

Vacuum and Electromagnetic Fields Treatment to Regenerate a Diffuse Mature Facial Scar Caused by Sulfuric Acid Assault.

Research RF Safe Research Library Jan 1, 2022

This article reports a case of a woman with an extended, mature facial scar from sulfuric acid assault treated with a procedure combining vacuum and electromagnetic fields. Before and after treatment, aesthetic appearance, motor function, and several skin physical parameters were evaluated. The authors report…

Frequency-tuned electromagnetic field therapy improves post-stroke motor function: A pilot randomized controlled trial.

Research RF Safe Research Library Jan 1, 2022

This pilot randomized, sham-controlled, double-blind trial evaluated extremely low frequency, low-intensity ENTF electromagnetic field therapy in subacute ischemic stroke patients with impaired upper extremity function. The per-protocol results reported greater improvements in motor function and disability outcomes…

Cone Beam Computed Tomography in the Assessment of the Effectiveness of Physical Therapy with the Use of the Electromagnetic Field Combined with Light Radiation Emitted by LEDs in the Treatment of Inflammation of the Paranasal Sinuses-A Case Study.

Research RF Safe Research Library Jan 1, 2022

This case study used cone beam computed tomography (CBCT) to assess a physical therapy approach combining extremely low frequency electromagnetic field (ELF-EMF) exposure with LED light for paranasal sinusitis. In one 39-year-old female patient, CBCT findings reportedly showed near-complete restoration of sinus…

EMF Antenna Exposure on a Multilayer Human Head Simulation for Alzheimer Disease Treatments.

Research RF Safe Research Library Jan 1, 2022

This study uses HFSS/EMPro simulations to model a 64 MHz antenna exposure on a multilayer human head to match parameters previously used in neuronal culture experiments. The simulations report achieving up to 0.6 W/kg maximum SAR and approximately 0.4–0.6 W/kg across head layers with a 1 A peak current pulse. The…

Extremely Low-Frequency Electromagnetic Fields Increase Cytokines in Human Hair Follicles through Wnt/β-Catenin Signaling.

Research RF Safe Research Library Jan 1, 2022

This in vitro/ex vivo study examined extremely low-frequency EMF exposure in human hair bulb spheroids and hair follicle organ cultures. The authors report no toxicity and increased expression of anagen-related markers and multiple cytokines/growth factors at 5–20 G, with 10 G for 60 minutes associated with increased…

The Potential of Cold Plasma and Electromagnetic Field as Stimulators of Natural Sweeteners Biosynthesis in Bertoni.

Research RF Safe Research Library Jan 1, 2022

This plant study evaluated whether short pre-sowing treatments with cold plasma or an electromagnetic field alter sweetener-related metabolites in stevia leaves. The authors report modest improvements in germination and a strong stimulation of steviol glycoside accumulation, with a larger increase in stevioside than…

Treatment with Pulsed Extremely Low Frequency Electromagnetic Field (PELF-EMF) Exhibit Anti-Inflammatory and Neuroprotective Effect in Compression Spinal Cord Injury Model.

Research RF Safe Research Library Jan 1, 2022

This animal study tested a pulsed extremely low frequency electromagnetic field (PELF-EMF) SEQEX device in a mouse compression spinal cord injury model. Mice received 4 hours of daily exposure for two months starting 2 hours after injury. The study reports reduced inflammatory and astrocyte activation markers,…

Pulsed and Discontinuous Electromagnetic Field Exposure Decreases Temozolomide Resistance in Glioblastoma by Modulating the Expression of O-Methylguanine-DNA Methyltransferase, Cyclin-D1, and p53.

Research RF Safe Research Library Jan 1, 2021

This in vitro study evaluated 50 Hz, 70 G electromagnetic field exposure in combination with temozolomide (TMZ) in T98 and A172 glioblastoma cell lines. The authors report that EMF plus TMZ increased cell death and reduced migration potential compared with controls. They also report increased p53 gene expression and…

Hydrogel-hydroxyapatite-monomeric collagen type-I scaffold with low-frequency electromagnetic field treatment enhances osteochondral repair in rabbits.

Research RF Safe Research Library Jan 1, 2021

This animal and in vitro study evaluated a composite osteochondral scaffold with bone marrow mesenchymal stem cells (BMSCs) combined with low-frequency electromagnetic field (EMF) stimulation. The authors report that EMF promoted BMSC proliferation and chondrogenic differentiation in vitro, partly via PI3K/AKT/mTOR…

A New Treatment for Stretch Marks and Skin Ptosis with Electromagnetic Fields and Negative Pressure: A Clinical and Histological Study.

Research RF Safe Research Library Jan 1, 2021

This clinical and histological study evaluated a combined electromagnetic fields and negative pressure treatment (V-EMF) for stretch marks and skin hypotonia. Sixty women aged 25–45 underwent 6 or 8 weekly sessions, with documentation via pictures, patient satisfaction, and biopsies. The authors report histological…

Modulation of Crystallinity through Radiofrequency Electromagnetic Fields in PLLA/Magnetic Nanoparticles Composites: A Proof of Concept.

Research RF Safe Research Library Jan 1, 2021

This materials proof-of-concept study explored using radiofrequency EMF to heat magnetic nanoparticles dispersed in PLLA to modulate polymer properties. Heating was monitored by infrared camera, and polymer changes were assessed by differential scanning calorimetry and nanoindentation. The authors report that EMF…

Sinusoidal electromagnetic fields accelerate bone regeneration by boosting the multifunctionality of bone marrow mesenchymal stem cells.

Research RF Safe Research Library Jan 1, 2021

This in vitro and rat study evaluated sinusoidal electromagnetic field (EMF) treatment of bone marrow mesenchymal stem cells (BMSCs) seeded on 3D-printed scaffolds for repairing critical-sized calvarial defects. The authors report that EMF-treated cell scaffolds accelerated bone defect repair in rats.…

Evaluation of the neuroprotective effects of Vitamin E on the rat substantia nigra neural cells exposed to electromagnetic field: An ultrastructural study.

Research RF Safe Research Library Jan 1, 2021

This rat study exposed animals to a 50 Hz, 3 mT electromagnetic field and assessed oxidative stress markers and substantia nigra ultrastructure. EMF exposure was associated with higher lipid peroxidation (MDA), lower SOD activity, and TEM-detected changes in nucleus/nuclear membrane and myelin sheath. Vitamin E…

A Prospective Comparative Study of Pulsed High-Intensity Laser Therapy and Pulsed Electromagnetic Field on Chronic Nonspecific Low Back Pain.

Research RF Safe Research Library Jan 1, 2021

This prospective comparative study randomized 51 adults with chronic nonspecific low back pain into HILT, pulsed EMF, or control groups for 8 weeks of treatment (twice weekly). Both HILT and EMF groups showed improvements in pain, disability, and lumbar flexion range of motion after the intervention. The study…

Effect of extremely low frequency electromagnetic field parameters on the proliferation of human breast cancer.

Research RF Safe Research Library Jan 1, 2021

This in vitro study tested how varying ELF-EMF parameters (frequency, flux density, duration, and continuous vs switching exposure) affect breast cancer and normal breast epithelial cell lines. The authors report that an optimized switching exposure pattern (7.83 ± 0.3 Hz, 1 mT) reduced viability of MDA-MB-231 cells…

Low-frequency electromagnetic field influences human oral mucosa keratinocyte viability in response to lipopolysaccharide or minocycline treatment in cell culture conditions.

Research RF Safe Research Library Jan 1, 2021

This in vitro study examined whether low-frequency electromagnetic field (LF-EMF) exposure affects viability of human oral mucosa keratinocytes. Apoptosis (early/late) and necrosis were measured by flow cytometry, including conditions with lipopolysaccharide (LPS) or minocycline. The authors report that LF-EMF, alone…

Synergistic effect of electromagnetic fields and nanomagnetic particles on osteogenesis through calcium channels and p-ERK signaling.

Research RF Safe Research Library Jan 1, 2021

This in vitro and animal study evaluated whether extremely low frequency EMF exposure (1 mT, 45 Hz, 8 h/day) combined with Fe-based nanomagnetic particles enhances osteogenesis. The authors report no detectable cytotoxicity and increased osteogenic markers/proteins with combined NMP + EMF exposure, alongside…

Electromagnetic Field in Alzheimer's Disease: A Literature Review of Recent Preclinical and Clinical Studies.

Research RF Safe Research Library Jan 1, 2020

This literature review summarizes recent preclinical and clinical research on electromagnetic fields (EMF) in relation to Alzheimer's disease (AD). It describes AD pathology involving amyloid-beta accumulation and tau hyperphosphorylation and notes limitations of current symptomatic treatments. The authors report…

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